The multifaceted mismatch-repair system (Q36448284)

14 August 2017

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title

The multifaceted mismatch-repair system (English)

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14 August 2017

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Josef Jiricny

1

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14 August 2017

1 May 2006

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Nature Reviews Molecular Cell Biology

14 August 2017

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14 August 2017

7

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14 August 2017

335-346

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14 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrm1907

14 August 2017

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cites work

Molecular mechanisms of DNA mismatch repair

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The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae

21 January 2018

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Mismatch repair proteins and mitotic genome stability

21 January 2018

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21 January 2018

Marginal-zone B cells

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Role of DNA mismatch repair defects in the pathogenesis of human cancer

21 January 2018

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DNA mismatch repair and colon cancer

31 March 2020

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Slippery DNA and diseases

31 March 2020

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31 March 2020

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Signaling mismatch repair in cancer

31 March 2020

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Eukaryotic DNA mismatch repair

31 March 2020

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Mammalian DNA mismatch repair

31 March 2020

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Mismatch repair and the hereditary non-polyposis colorectal cancer syndrome (HNPCC)

31 March 2020

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DNA mismatch correction in a defined system

31 March 2020

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Identification of base mismatches recognized by the heteroduplex-DNA-repair system of Streptococcus pneumoniae

31 March 2020

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Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli

31 March 2020

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d(GATC) sequences influence Escherichia coli mismatch repair in a distance-dependent manner from positions both upstream and downstream of the mismatch

31 March 2020

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Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines

31 March 2020

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GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

31 March 2020

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Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells

31 March 2020

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hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

31 March 2020

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

31 March 2020

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HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions

31 March 2020

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Superfamily of UvrA-related NTP-binding proteins. Implications for rational classification of recombination/repair systems

31 March 2020

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hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

31 March 2020

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hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha

31 March 2020

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Photocross-linking of the NH2-terminal region of Taq MutS protein to the major groove of a heteroduplex DNA.

31 March 2020

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Mismatch recognition and DNA-dependent stimulation of the ATPase activity of hMutSalpha is abolished by a single mutation in the hMSH6 subunit.

31 March 2020

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The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch

31 March 2020

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Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism

31 March 2020

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Analysis of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 and MLH1-PMS1 complexes with DNA using a reversible DNA end-blocking system.

31 March 2020

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hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA

31 March 2020

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DNA mismatch repair: MutS structures bound to mismatches.

31 March 2020

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The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

31 March 2020

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Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

31 March 2020

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Mismatch repair: the praying hands of fidelity

31 March 2020

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DNA-dependent activation of the hMutSalpha ATPase

31 March 2020

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Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair

31 March 2020

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ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

31 March 2020

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Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites

31 March 2020

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GHKL, an emergent ATPase/kinase superfamily

31 March 2020

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Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair

31 March 2020

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Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.

31 March 2020

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Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse

31 March 2020

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Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair

31 March 2020

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The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations

31 March 2020

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The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair

31 March 2020

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In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination.

31 March 2020

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Visualization of mismatch repair in bacterial cells

31 March 2020

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DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes

31 March 2020

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Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha

31 March 2020

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hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.

31 March 2020

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Mismatch repair in human nuclear extracts: effects of internal DNA-hairpin structures between mismatches and excision-initiation nicks on mismatch correction and mismatch-provoked excision

31 March 2020

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Signaling from DNA mispairs to mismatch-repair excision sites despite intervening blockades

31 March 2020

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Analysis of the human MutLalpha.MutSalpha complex

31 March 2020

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Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis

31 March 2020

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hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci

31 March 2020

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Transfer of the MSH2.MSH6 complex from proliferating cell nuclear antigen to mispaired bases in DNA.

31 March 2020

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hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair

31 March 2020

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EXO1-A multi-tasking eukaryotic nuclease.

31 March 2020

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Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

31 March 2020

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Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs

31 March 2020

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DNA polymerase delta is required for human mismatch repair in vitro

31 March 2020

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The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair

31 March 2020

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Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A

31 March 2020

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Human exonuclease I is required for 5' and 3' mismatch repair

31 March 2020

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Evidence for involvement of HMGB1 protein in human DNA mismatch repair

31 March 2020

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A defined human system that supports bidirectional mismatch-provoked excision

31 March 2020

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Reconstitution of 5'-directed human mismatch repair in a purified system

31 March 2020

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Mechanism of 5'-directed excision in human mismatch repair

31 March 2020

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Human mismatch repair: reconstitution of a nick-directed bidirectional reaction

31 March 2020

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Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair

31 March 2020

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Mismatch repair and DNA damage signalling

31 March 2020

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Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

31 March 2020

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Mechanisms of tolerance to DNA damaging therapeutic drugs

31 March 2020

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Methylation-induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1

31 March 2020

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Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.

31 March 2020

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Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase

31 March 2020

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Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae

31 March 2020

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Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine.

31 March 2020

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Cytotoxic mechanism of 6-thioguanine: hMutSalpha, the human mismatch binding heterodimer, binds to DNA containing S6-methylthioguanine

31 March 2020

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Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway

31 March 2020

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Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells

31 March 2020

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Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins.

31 March 2020

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Cellular processing of platinum anticancer drugs

31 March 2020

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Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin

31 March 2020

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DNA mismatch repair proteins promote apoptosis and suppress tumorigenesis in response to UVB irradiation: an in vivo study

31 March 2020

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Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes

31 March 2020

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Sensitivity to DNA cross-linking chemotherapeutic agents in mismatch repair-defective cells in vitro and in xenografts

31 March 2020

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MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

31 March 2020

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Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2

31 March 2020

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ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage

31 March 2020

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An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

31 March 2020

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Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility

31 March 2020

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DNA mismatch repair and genetic instability

31 March 2020

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Meiotic recombination intermediates and mismatch repair proteins

31 March 2020

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The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants.

31 March 2020

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hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes

31 March 2020

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Meiotic recombination: sealing the partnership at the junction

31 March 2020

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Meiotic arrest and aneuploidy in MLH3-deficient mice

31 March 2020

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Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

31 March 2020

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Mismatch repair co-opted by hypermutation.

31 March 2020

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AID and mismatch repair in antibody diversification

31 March 2020

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Immunity through DNA deamination

31 March 2020

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The generation of antibody diversity through somatic hypermutation and class switch recombination

31 March 2020

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Identifying protein-protein interactions in somatic hypermutation

31 March 2020

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MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes

31 March 2020

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Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases

31 March 2020

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Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

31 March 2020

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(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition

31 March 2020

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31 March 2020

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7 January 2021

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Identifiers

DOI

10.1038/NRM1907

1 reference

14 August 2017

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PubMed ID

16612326