Beta-lactamase inhibitors: evolving compounds for evolving resistance targets (Q35906971)

11 August 2017

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title

Beta-lactamase inhibitors: evolving compounds for evolving resistance targets (English)

1 reference

11 August 2017

Nafsika H Georgopapadakou

series ordinal

1

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PubMed ID

15461559

11 August 2017

language of work or name

English

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publication date

1 October 2004

1 reference

Expert Opinion on Investigational Drugs

11 August 2017

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11 August 2017

13

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11 August 2017

10

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11 August 2017

1307-1318

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Recent Developments in the Field of β-Lactam Antibiotics

11 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Penicillin-binding proteins and bacterial resistance to beta-lactams

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Serine beta-lactamases and penicillin-binding proteins

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Version 2000: the new beta-lactamases of Gram-negative bacteria at the dawn of the new millennium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Beta-lactamases: a survey of protein diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

The structure of β-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

A comparative study of class-D beta-lactamases

21 January 2018

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A functional classification scheme for beta-lactamases and its correlation with molecular structure

21 January 2018

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Sensitivity of Escherichia coli to various beta-lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic beta-lactamases: a quantitative predictive treatment

21 January 2018

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Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat

21 January 2018

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Chromosome-encoded Ambler class A beta-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum beta-lactamases

21 January 2018

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Epidemiology of conjugative plasmid-mediated AmpC beta-lactamases in the United States.

21 January 2018

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Comparative activity of beta-lactam agents (carbapenem excepted) against Pseudomonas aeruginosa strains with CARB or OXA beta-lactamases

21 January 2018

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Role of the omega-loop in the activity, substrate specificity, and structure of class A beta-lactamase

21 January 2018

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Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure

21 January 2018

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Structure of the SHV-1 beta-lactamase

21 January 2018

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Site-saturation mutagenesis and three-dimensional modelling of ROB-1 define a substrate binding role of Ser130 in class A beta-lactamases

21 January 2018

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Inhibition of the broad spectrum nonmetallocarbapenamase of class A (NMC-A) beta-lactamase from Enterobacter cloacae by monocyclic beta-lactams.

21 January 2018

1 reference

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Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Crystal structure of the class D beta-lactamase OXA-10

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10 beta-lactamase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Critical involvement of a carbamylated lysine in catalytic function of class D -lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Predicting the emergence of antibiotic resistance by directed evolution and structural analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Evolution of the serine beta-lactamases: past, present and future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Structural determinants and hydrogen-bond network of the mononuclear zinc(II)-beta-lactamase active site.

21 January 2018

1 reference

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21 January 2018

b-Lactamase inhibitors

1 reference

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In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with beta-lactams against epidemiologically characterized multidrug-resistant Acinetobacter baumannii strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

6-beta-bromopenicillanic acid, a potent beta-lactamase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

In-vitro evaluation of ampicillin/brobactam and comparison with other β-lactam antibiotics

21 January 2018

1 reference

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Treatment of Acinetobacter spp infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Kinetic studies on the inactivation of Escherichia coli RTEM β-lactamase by clavulanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Inhibitor-resistant TEM beta-lactamases: phenotypic, genetic and biochemical characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States

21 January 2018

1 reference

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Tazobactam inactivation of SHV-1 and the inhibitor-resistant Ser130 -->Gly SHV-1 beta-lactamase: insights into the mechanism of inhibition

21 January 2018

1 reference

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Molecular basis of bacterial outer membrane permeability

21 January 2018

1 reference

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Klebsiella pneumoniae isolate from South Africa with multiple TEM, SHV and AmpC beta-lactamases

21 January 2018

1 reference

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Molecular and biochemical characterization of OXA-45, an extended-spectrum class 2d' beta-lactamase in Pseudomonas aeruginosa.

21 January 2018

1 reference

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Beta-lactamase patterns and betalactam/clavulanic acid resistance in Escherichia coli isolated from fecal samples from healthy volunteers.

21 January 2018

1 reference

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Using steric hindrance to design new inhibitors of class C beta-lactamases

21 January 2018

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Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design

21 January 2018

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Inhibition of AmpC beta-lactamase through a destabilizing interaction in the active site

21 January 2018

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Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae

21 January 2018

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Inhibition of class C beta-lactamases: structure of a reaction intermediate with a cephem sulfone

21 January 2018

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Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases

21 January 2018

1 reference

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In vitro activities of novel oxapenems, alone and in combination with ceftazidime, against gram-positive and gram-negative organisms

21 January 2018

1 reference

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In vitro and in vivo activities of AM-112, a novel oxapenem.

21 January 2018

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Pharmacokinetic studies and renal dehydropeptidase stability of the new beta-lactamase inhibitor BRL 42715 in animals

21 January 2018

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Inhibition of Class A and Class C β-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate,

21 January 2018

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The complexed structure and antimicrobial activity of a non-β-lactam inhibitor of AmpC β-lactamase

21 January 2018

1 reference

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Mechanism of inhibition of the class C beta-lactamase of Enterobacter cloacae P99 by phosphonate monoesters

21 January 2018

1 reference

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Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog

21 January 2018

1 reference

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Inhibition of beta-lactamases by monocyclic acyl phosph(on)ates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1307

Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa

21 January 2018

1 reference

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Role of OmpD2 and chromosomal β-lactamase in carbapenem resistance in clinical isolates of Pseudomonas aeruginosa

21 January 2018

1 reference

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Alterations of susceptibility of Pseudomonas aeruginosa by overproduction of multidrug efflux systems, MexAB-OprM, MexCD-OprJ, and MexXY/OprM to carbapenems: substrate specificities of the efflux systems

21 January 2018

1 reference

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Extrusion of penem antibiotics by multicomponent efflux systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa

21 January 2018

1 reference

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Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa

21 January 2018

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Multiple antibiotic resistance in Stenotrophomonas maltophilia: involvement of a multidrug efflux system

21 January 2018

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10.1517/13543784.13.10.1307

21 January 2018

Identifiers

DOI

1 reference

11 August 2017

1 reference

PubMed ID

15461559