An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis (Q35908707)

11 August 2017

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis (English)

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11 August 2017

2

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15 June 2020

Walter W Chen

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3

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15 June 2020

David M. Sabatini

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6

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15 June 2020

4

Elizaveta Freinkman

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15 June 2020

1

Kıvanç Birsoy

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15 June 2020

author name string

Monther Abu-Remaileh

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5

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15 June 2020

language of work or name

English

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publication date

1 July 2015

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11 August 2017

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15 June 2020

volume

162

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15 June 2020

issue

3

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15 June 2020

page(s)

540-551

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Regulation of mammalian nucleotide metabolism and biosynthesis

15 June 2020

cites work

1 reference

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Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies

11 July 2018

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Mitochondria as signaling organelles

11 July 2018

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Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

11 July 2018

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Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

11 July 2018

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

11 July 2018

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Hallmarks of a new era in mitochondrial biochemistry

11 July 2018

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Genetic screens in human cells using the CRISPR-Cas9 system

11 July 2018

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Aspartate aminotransferase: an old dog teaches new tricks

11 July 2018

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The Genotype-Tissue Expression (GTEx) project

11 July 2018

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Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

11 July 2018

1 reference

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A mitochondrial bioenergetic etiology of disease

11 July 2018

1 reference

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Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.

11 July 2018

1 reference

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Human mitochondrial DNA: roles of inherited and somatic mutations

11 July 2018

1 reference

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The dynamic regulation of NAD metabolism in mitochondria

11 July 2018

1 reference

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Treatment for mitochondrial disorders

11 July 2018

1 reference

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

11 July 2018

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Monogenic mitochondrial disorders

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Pyruvate therapy for mitochondrial DNA depletion syndrome

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

11 July 2018

1 reference

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Pathogenesis and treatment of mitochondrial myopathies: recent advances

11 July 2018

1 reference

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

mtDNA mutations increase tumorigenicity in prostate cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism

11 July 2018

1 reference

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Pathophysiological relevance of mitochondria in NAD(+) metabolism.

11 July 2018

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Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Mitochondria and neuronal survival

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Mitochondrial diseases in man and mouse

11 July 2018

1 reference

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Mitochondria and apoptosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Isolation of human cell lines lacking mitochondrial DNA.

11 July 2018

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Origin and functional consequences of the complex I defect in Parkinson's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

The cellular production of hydrogen peroxide

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Cytoplasmic genetics of mammalian cells: Conditional sensitivity to mitochondrial inhibitors and isolation of new mutant phenotypes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

The Metabolic Significance of the Malate-Aspartate Cycle in Heart

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522279

Familial mitochondrial encephalomyopathy (MERRF): genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease

11 July 2018

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12 December 2020

Concerted loss of cyclooxygenase and peroxidase activities from prostaglandin H synthase upon proteolytic attack

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12 December 2020

Mitochondrial deafness

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12 December 2020

A 4-base pair deletion in the mitochondrial cytochrome b gene associated with parkinsonism/MELAS overlap syndrome

1 reference

12 December 2020

Efficacy of pyruvate therapy in patients with mitochondrial disease: a semi-quantitative clinical evaluation study

1 reference

12 December 2020

Pyruvate blocks expression of sensitivity to antimycin A and chloramphenicol

1 reference

12 December 2020

Amino acid concentrations in serum and aqueous humor from subjects with extreme myopia or senile cataract

1 reference

12 December 2020

Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides

1 reference

12 December 2020

Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells

1 reference

12 December 2020

An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production

1 reference

12 December 2020

10.1016/J.CELL.2015.07.016

Identifiers

DOI

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15 June 2020

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15 June 2020

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