Target-mediated pharmacokinetic and pharmacodynamic model of exendin-4 in rats, monkeys, and humans (Q35913076)

11 August 2017

Target-mediated pharmacokinetic and pharmacodynamic model of exendin-4 in rats, monkeys, and humans (English)

1 reference

11 August 2017

1 reference

ChEBI release 2020-05-28

1 reference

1 reference

2

William J Jusko

1 reference

11 August 2017

Wei Gao

1

1 reference

11 August 2017

15 February 2012

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Drug Metabolism and Disposition

11 August 2017

1 reference

11 August 2017

40

1 reference

11 August 2017

5

1 reference

11 August 2017

990-997

1 reference

Pharmacokinetic and pharmacodynamic modeling of exendin-4 in type 2 diabetic Goto-Kakizaki rats

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Interspecies scaling of receptor-mediated pharmacokinetics and pharmacodynamics of type I interferons

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Pharmacodynamics of glucose regulation by methylprednisolone. II. normal rats

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Expression of the GLP-1 receptor in mouse, rat, and human pancreas

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Exenatide: a review of its use in patients with type 2 diabetes mellitus (as an adjunct to metformin and/or a sulfonylurea).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Pharmacokinetics and pharmacodynamics of exenatide following alternate routes of administration

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

ON THE DONNAN EQUILIBRIUM AND THE EQUATION OF GIBBS.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Mechanisms of action of glucagon-like peptide 1 in the pancreas

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Investigation of exenatide elimination and its in vivo and in vitro degradation.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336795

Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22338110

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of human and rat glucagon-like peptide-1 receptors in the neurointermediate lobe: lack of coupling to either stimulation or inhibition of adenylyl cyclase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22338110

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Single- and multiple-dose pharmacokinetics of exendin-4 in rhesus monkeys

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22338110

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/DMD.111.042291

1 reference

11 August 2017

1 reference

PMC publication ID

3336795

11 August 2017

PubMed publication ID

22338110

1 reference

PMC publication ID

3336795