Hepatitis C drug discovery: in vitro and in vivo systems and drugs in the pipeline (Q35917417)

11 August 2017

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title

Hepatitis C drug discovery: in vitro and in vivo systems and drugs in the pipeline (English)

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11 August 2017

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Mingjun Huang

1

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11 August 2017

Milind Deshpande

series ordinal

2

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11 August 2017

publication date

1 June 2004

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Expert Review of Anti-infective Therapy

11 August 2017

published in

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11 August 2017

volume

2

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11 August 2017

issue

3

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11 August 2017

page(s)

375-388

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The scientific challenge of hepatitis C.

11 August 2017

cites work

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Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

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The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein

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To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon.

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Synthesis of a novel hepatitis C virus protein by ribosomal frameshift

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Alternate translation occurs within the core coding region of the hepatitis C viral genome

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Two alternative translation mechanisms are responsible for the expression of the HCV ARFP/F/core+1 coding open reading frame

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Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus

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Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein

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Binding of hepatitis C virus to CD81

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CD81 is required for hepatitis C virus glycoprotein-mediated viral infection

21 January 2018

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The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus

21 January 2018

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L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus

21 January 2018

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DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2

21 January 2018

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Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor

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Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes

21 January 2018

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Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

21 January 2018

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

21 January 2018

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Efficient initiation of HCV RNA replication in cell culture

21 January 2018

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Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations

21 January 2018

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Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

21 January 2018

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Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

21 January 2018

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Persistent Replication of Hepatitis C Virus Replicons Expressing the -Lactamase Reporter in Subpopulations of Highly Permissive Huh7 Cells

21 January 2018

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Subgenomic hepatitis C virus replicons inducing expression of a secreted enzymatic reporter protein

21 January 2018

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Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells

21 January 2018

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21 January 2018

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Establishment of a hepatitis C virus subgenomic replicon derived from human hepatocytes infected in vitro

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Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon

21 January 2018

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Replication of Hepatitis C Virus Subgenomes in Nonhepatic Epithelial and Mouse Hepatoma Cells

21 January 2018

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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

21 January 2018

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Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

21 January 2018

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Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

21 January 2018

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Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

21 January 2018

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Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

21 January 2018

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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

21 January 2018

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Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro

21 January 2018

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Comparison of tamarins and marmosets as hosts for GBV-B infections and the effect of immunosuppression on duration of viremia

21 January 2018

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Development of a GB virus B marmoset model and its validation with a novel series of hepatitis C virus NS3 protease inhibitors

21 January 2018

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Cell clones selected from the Huh7 human hepatoma cell line support efficient replication of a subgenomic GB virus B replicon

21 January 2018

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Hep3B Human Hepatoma Cells Support Replication of the Wild-Type and a 5'-End Deletion Mutant GB Virus B Replicon

21 January 2018

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Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors

21 January 2018

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Hepatitis C virus replicons: potential role for drug development

21 January 2018

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The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

21 January 2018

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In vitro infection of adult normal human hepatocytes in primary culture by hepatitis C virus

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/14787210.2.3.375

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release_vgnbtrmoczfwha4aoumfexqqbq

11 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vgnbtrmoczfwha4aoumfexqqbq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference