A-type lamins: guardians of the soma? (Q35934217)

11 August 2017

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title

A-type lamins: guardians of the soma? (English)

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11 August 2017

Chris J Hutchison

1

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11 August 2017

Howard J Worman

series ordinal

2

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11 August 2017

publication date

1 November 2004

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11 August 2017

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11 August 2017

volume

6

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11 August 2017

issue

11

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11 August 2017

page(s)

1062-1067

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cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins

11 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

The conserved carboxy-terminal cysteine of nuclear lamins is essential for lamin association with the nuclear envelope

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Lamins: building blocks or regulators of gene expression?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

A lamin-independent pathway for nuclear envelope assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Disruption of nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Multiple and surprising new functions for emerin, a nuclear membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Mechanosensation through integrins: cells act locally but think globally

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Nuclear organization of DNA replication in primary mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

The carboxyl-terminal region common to lamins A and C contains a DNA binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Unusual type of benign x-linked muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Emerin deficiency at the nuclear membrane in patients with Emery-Dreifuss muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Direct interaction between emerin and lamin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Structure of the globular tail of nuclear lamin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Characterization of adiposity and metabolism in Lmna-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

A new clinical condition linked to a novel mutation in lamins A and C with generalized lipoatrophy, insulin-resistant diabetes, disseminated leukomelanodermic papules, liver steatosis, and cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

The Hutchinson-Gilford progeria syndrome. Report of 4 cases and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Lamin a truncation in Hutchinson-Gilford progeria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

A progeroid syndrome in mice is caused by defects in A-type lamins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

LMNA mutations in atypical Werner's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Novel lamin A/C gene (LMNA) mutations in atypical progeroid syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

The nuclear lamina and inherited disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Ultrastructural abnormality of sarcolemmal nuclei in Emery-Dreifuss muscular dystrophy (EDMD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Expression of a mutant lamin A that causes Emery-Dreifuss muscular dystrophy inhibits in vitro differentiation of C2C12 myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

Remodelling of the nuclear lamina and nucleoskeleton is required for skeletal muscle differentiation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

The nuclear lamina is a meshwork of intermediate-type filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

cDNA cloning of a germ cell specific lamin B3 from mouse spermatocytes and analysis of its function by ectopic expression in somatic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

7 January 2021

Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

7 January 2021

Clinical and molecular genetic spectrum of autosomal dominant Emery-Dreifuss muscular dystrophy due to mutations of the lamin A/C gene

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

7 January 2021

Localization of the gene for familial partial lipodystrophy (Dunnigan variety) to chromosome 1q21–22

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

7 January 2021

The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

7 January 2021

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

7 January 2021

Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

7 January 2021

Architectural abnormalities in muscle nuclei. Ultrastructural differences between X-linked and autosomal dominant forms of EDMD

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

7 January 2021

Increased solubility of lamins and redistribution of lamin C in X-linked Emery-Dreifuss muscular dystrophy fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1062

7 January 2021

Identifiers

DOI

10.1038/NCB1104-1062

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11 August 2017

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