Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. (Q35935751)

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English	Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.	scientific article

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27 January 2020

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation (English)

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27 January 2020

Christos Tsatsanis

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27 January 2020

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27 January 2020

Aristides G Eliopoulos

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27 January 2020

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Oksana B Serebrennikova

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27 January 2020

Changchuin Mao

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27 January 2020

Wenying Ren

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27 January 2020

Linda D Siracusa

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27 January 2020

Khashayarsha Khazaie

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27 January 2020

Philip N Tsichlis

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27 January 2020

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26 March 2012

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27 January 2020

Proceedings of the National Academy of Sciences of the United States of America

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27 January 2020

109

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27 January 2020

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27 January 2020

E1082-91

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27 January 2020

Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.

1 reference

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2 October 2017

Regulatory T-cell stability and plasticity in mucosal and systemic immune systems

1 reference

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2 October 2017

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice

1 reference

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2 October 2017

Inflammation and colon cancer

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2 October 2017

Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice.

1 reference

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2 October 2017

In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction

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2 October 2017

Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis

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2 October 2017

NF-kappaB as a critical link between inflammation and cancer

1 reference

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2 October 2017

Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.

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2 October 2017

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

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2 October 2017

Stromal regulatory T-cells are associated with a favourable prognosis in gastric cancer of the cardia

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2 October 2017

TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells

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2 October 2017

Inflammation and colorectal cancer

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2 October 2017

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis

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2 October 2017

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?

1 reference

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2 October 2017

Immunoregulatory functions of mTOR inhibition.

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2 October 2017

Myeloid-derived suppressor cells: linking inflammation and cancer

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2 October 2017

Regulatory lymphocytes and intestinal inflammation.

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2 October 2017

Myeloid-derived suppressor cells as regulators of the immune system

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2 October 2017

Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

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2 October 2017

The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis

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2 October 2017

Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii

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2 October 2017

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth

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2 October 2017

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3344997

2 October 2017

Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3344997

2 October 2017

Mast cells are an essential hematopoietic component for polyp development

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2 October 2017

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology

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2 October 2017

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

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2 October 2017

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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2 October 2017

IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage

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2 October 2017

Signaling pathways in intestinal development and cancer

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2 October 2017

Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

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2 October 2017

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

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2 October 2017

Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps

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2 October 2017

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

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2 October 2017

Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

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2 October 2017

Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis

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2 October 2017

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses

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2 October 2017

Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase

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2 October 2017

Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation

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2 October 2017

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

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11 July 2018

Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration.

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11 July 2018

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

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11 July 2018

The TSC-mTOR signaling pathway regulates the innate inflammatory response

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24 September 2018

CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice.

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24 September 2018

Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

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24 September 2018

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

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24 September 2018

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1115098109

21 January 2018

Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1115098109

21 January 2018

IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1115098109

21 January 2018

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

1 reference

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21 January 2018

COX-2 inhibitors for colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451924

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451924

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451924

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacterial infection promotes colon tumorigenesis in Apc(Min/+) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451924

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451924

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1115098109

1 reference

Europe PubMed Central

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27 January 2020

2012PNAS..109E1082S

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27 January 2020

1 reference

Europe PubMed Central

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27 January 2020

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