Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage (Q35948990)

11 August 2017

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage (English)

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11 August 2017

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Jonathan R Hall

1

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11 August 2017

Evelyn Kow

2

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11 August 2017

Kathleen R Nevis

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11 August 2017

Chiajung Karen Lu

4

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11 August 2017

K Scott Luce

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11 August 2017

Qing Zhong

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11 August 2017

Jeanette Gowen Cook

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11 August 2017

13 June 2007

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Molecular Biology of the Cell

11 August 2017

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18

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9

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11 August 2017

3340-3350

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describes a project that uses

11 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1951745/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

1 reference

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Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.

2 October 2017

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The functional role of Cdc6 in S-G2/M in mammalian cells

2 October 2017

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PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination

2 October 2017

1 reference

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An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage

2 October 2017

1 reference

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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

2 October 2017

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BH3-ligand regulates access of MCL-1 to its E3 ligase

2 October 2017

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Right place, right time, and only once: replication initiation in metazoans

2 October 2017

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CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

2 October 2017

1 reference

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Human CDK2 inhibition modifies the dynamics of chromatin-bound minichromosome maintenance complex and replication protein A.

2 October 2017

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p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation

2 October 2017

1 reference

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Disruption of mechanisms that prevent rereplication triggers a DNA damage response

2 October 2017

1 reference

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

2 October 2017

1 reference

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

2 October 2017

1 reference

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Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase

2 October 2017

1 reference

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Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones

2 October 2017

1 reference

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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

2 October 2017

1 reference

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Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein

2 October 2017

1 reference

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Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional contro

2 October 2017

1 reference

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Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage

2 October 2017

1 reference

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Regulation of early events in chromosome replication

2 October 2017

1 reference

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ORC-associated replication factors as biomarkers for cancer.

2 October 2017

1 reference

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Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

2 October 2017

1 reference

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Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

2 October 2017

1 reference

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

2 October 2017

1 reference

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Loss of Geminin induces rereplication in the presence of functional p53

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex

2 October 2017

1 reference

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The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation

2 October 2017

1 reference

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Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

2 October 2017

1 reference

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Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

2 October 2017

1 reference

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The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells

2 October 2017

1 reference

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Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

2 October 2017

1 reference

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Caspase-3-mediated Cleavage of Cdc6 Induces Nuclear Localization of p49-truncated Cdc6 and Apoptosis

2 October 2017

1 reference

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The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

2 October 2017

1 reference

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A p53-dependent checkpoint pathway prevents rereplication

2 October 2017

1 reference

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Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.

2 October 2017

1 reference

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An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Control of DNA replication licensing in a cell cycle

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

DNA replication in eukaryotic cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Control of DNA replication and chromosome ploidy by geminin and cyclin A

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Oncogenic potential of the DNA replication licensing protein CDT1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Replication licensing--defining the proliferative state?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Analysis of Cdc6 function in the assembly of mammalian prereplication complexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Cell cycle checkpoint signaling through the ATM and ATR kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951745

Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells

14 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17567951

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cdc6 expression as a marker of proliferative activity in brain tumors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17567951

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1091/MBC.E07-02-0173

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

17567951

1 reference