Tests of the extension and deadbolt models of integrin activation (Q35951243)

11 August 2017

Tests of the extension and deadbolt models of integrin activation (English)

1 reference

11 August 2017

Jieqing Zhu

1

1 reference

11 August 2017

Brian Boylan

2

1 reference

11 August 2017

Bing-Hao Luo

3

1 reference

11 August 2017

Peter J Newman

4

1 reference

11 August 2017

Timothy A Springer

5

1 reference

11 August 2017

language of work or name

English

0 references

publication date

13 February 2007

1 reference

Journal of Biological Chemistry

11 August 2017

1 reference

11 August 2017

282

1 reference

11 August 2017

16

1 reference

11 August 2017

11914-11920

1 reference

Integrin structures and conformational signaling

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Integrin structure, allostery, and bidirectional signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Epitope mapping of monoclonal antibody to integrin alphaL beta2 hybrid domain suggests different requirements of affinity states for intercellular adhesion molecules (ICAM)-1 and ICAM-3 binding

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Electron tomography reveals diverse conformations of integrin alphaIIbbeta3 in the active state

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Dual function for a unique site within the beta2I domain of integrin alphaMbeta2.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

The integrin alpha L beta 2 hybrid domain serves as a link for the propagation of activation signal from its stalk regions to the I-like domain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Integrins: dynamic scaffolds for adhesion and signaling in platelets

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Structure of integrin alpha5beta1 in complex with fibronectin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

New insights into the structural basis of integrin activation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

A site involving the "hybrid" and PSI homology domains of GPIIIa (beta 3-integrin subunit) is a common target for antibodies associated with quinine-induced immune thrombocytopenia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Integrins: bidirectional, allosteric signaling machines

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Integrin activation and structural rearrangement

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Crystal structure of the extracellular segment of integrin alpha Vbeta3

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Quantitation of membrane glycoprotein IIIa on intact human platelets using the monoclonal antibody, AP-3.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

A novel regulatory epitope defined by a murine monoclonal antibody to the platelet GPIIb-IIIa complex (alpha IIb beta 3 integrin).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952534

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

27 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700249200

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700249200

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700249200

Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700249200

Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700249200

Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700249200

Identification of critical residues for regulation of integrin activation in the beta6-alpha7 loop of the integrin beta3 I-like domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700249200

Activation of leukocyte beta2 integrins by conversion from bent to extended conformations

21 January 2018

1 reference

12 December 2020

A conformation-dependent epitope of human platelet glycoprotein IIIa

1 reference

12 December 2020

Further characterization of the loop structure of platelet glycoprotein IIIa: partial mapping of functionally significant glycoprotein IIIa epitopes

1 reference

12 December 2020

The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3

1 reference

12 December 2020

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

12 December 2020

Quantitation of soluble fibrinogen binding to platelets by fluorescence-activated flow cytometry

1 reference

12 December 2020

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M700249200

1 reference

11 August 2017

1 reference

11 August 2017

1 reference