An engineered lantibiotic synthetase that does not require a leader peptide on its substrate (Q35952908)

11 August 2017

An engineered lantibiotic synthetase that does not require a leader peptide on its substrate (English)

1 reference

11 August 2017

5

Wilfred A van der Donk

1 reference

11 August 2017

Trent J Oman

1

1 reference

11 August 2017

Patrick J Knerr

series ordinal

2

1 reference

11 August 2017

Noah A Bindman

series ordinal

3

1 reference

11 August 2017

Juan E Velásquez

series ordinal

4

1 reference

11 August 2017

language of work or name

English

0 references

publication date

11 April 2012

1 reference

Journal of the American Chemical Society

11 August 2017

1 reference

11 August 2017

134

1 reference

11 August 2017

16

1 reference

11 August 2017

6952-6955

1 reference

Discovery, biosynthesis, and engineering of lantipeptides

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Ribosomal route to small-molecule diversity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

A mass spectrometry-guided genome mining approach for natural product peptidogenomics

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Nine post-translational modifications during the biosynthesis of cinnamycin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Production of lantipeptides in Escherichia coli.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Genome mining for ribosomally synthesized natural products

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

The dawning of a 'Golden era' in lantibiotic bioengineering.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Fundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Photochemical cleavage of leader peptides.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Adding new chemistries to the genetic code

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Follow the leader: the use of leader peptides to guide natural product biosynthesis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Chapter 22. Whole-cell generation of lantibiotic variants.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Post-translational modification in microviridin biosynthesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

The importance of the leader sequence for directing lanthionine formation in lacticin 481.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

In vitro reconstitution and substrate specificity of a lantibiotic protease.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Discovery of a widely distributed toxin biosynthetic gene cluster

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Gene family encoding the major toxins of lethal Amanita mushrooms

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

The leader peptide is not required for post-translational modification by lacticin 481 synthetase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Two enzymes catalyze the maturation of a lasso peptide in Escherichia coli

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

On the substrate specificity of dehydration by lacticin 481 synthetase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Construction, expression, and characterization of a novel fully activated recombinant single-chain hepatitis C virus protease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Systematic structure-activity analysis of microcin J25.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Congeneric lantibiotics from ribosomal in vivo peptide synthesis with noncanonical amino acids.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Dissection of the bridging pattern of bovicin HJ50, a lantibiotic containing a characteristic disulfide bridge.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Evaluation of essential and variable residues of nukacin ISK-1 by NNK scanning.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Maturation of McjA precursor peptide into active microcin MccJ25.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Lanthionine introduction into nukacin ISK-1 prepeptide by co-expression with modification enzyme NukM in Escherichia coli

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350211

In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C-C bond as a post-translational modification

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22480178

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Determining sites of interaction between prenisin and its modification enzymes NisB and NisC

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22480178

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expressed protein ligation to probe regiospecificity of heterocyclization in the peptide antibiotic microcin B17

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22480178

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JA3017297

1 reference

11 August 2017

1 reference

11 August 2017

1 reference