TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia. (Q35956532)

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English	TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.	scientific article

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scholarly article

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26 January 2020

TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia (English)

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26 January 2020

toll-like receptor

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Vladimir Toshchakov

9

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26 January 2020

author name string

Anguo Liu

1

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26 January 2020

Ping Gong

2

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26 January 2020

Sang W Hyun

3

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26 January 2020

Kent Z Q Wang

4

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26 January 2020

Elizabeth A Cates

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26 January 2020

Darren Perkins

6

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26 January 2020

Douglas D Bannerman

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26 January 2020

Adam C Puché

8

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26 January 2020

Shengyun Fang

10

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26 January 2020

Philip E Auron

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26 January 2020

Stefanie N Vogel

12

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26 January 2020

Simeon E Goldblum

13

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publication date

23 March 2012

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26 January 2020

number of pages

14

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Journal of Biological Chemistry

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26 January 2020

287

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26 January 2020

20

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26 January 2020

16132-16145

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26 January 2020

TRAF6 is autoinhibited by an intramolecular interaction which is counteracted by trans-ubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351307

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

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2 October 2017

Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

1 reference

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2 October 2017

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

1 reference

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The E3 ligase TRAF6 regulates Akt ubiquitination and activation

1 reference

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2 October 2017

Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins.

1 reference

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2 October 2017

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

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TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL

1 reference

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Functional characterization of bovine TIRAP and MyD88 in mediating bacterial lipopolysaccharide-induced endothelial NF-kappaB activation and apoptosis

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Structures of the toll-like receptor family and its ligand complexes

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2 October 2017

The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL

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2 October 2017

Structure and dynamic regulation of Src-family kinases

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SRC family kinases as potential therapeutic targets for malignancies and immunological disorders

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2 October 2017

TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia

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2 October 2017

Src family kinases: regulation of their activities, levels and identification of new pathways

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2 October 2017

IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

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2 October 2017

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling.

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Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

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2 October 2017

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

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2 October 2017

Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination

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2 October 2017

TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src.

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2 October 2017

Lipopolysaccharide signaling in endothelial cells

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Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia

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2 October 2017

TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages.

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2 October 2017

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

1 reference

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2 October 2017

Toll-like receptor signalling

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2 October 2017

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2 October 2017

TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway

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2 October 2017

Distinct molecular mechanism for initiating TRAF6 signalling

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Negative regulation of Lck by Cbl ubiquitin ligase

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2 October 2017

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Ubiquitin-mediated degradation of active Src tyrosine kinase

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2 October 2017

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2 October 2017

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11 July 2018

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11 July 2018

Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs.

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24 September 2018

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24 September 2018

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24 September 2018

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24 September 2018

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1 reference

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12 December 2020

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Receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice

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12 December 2020

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10.1074/JBC.M111.310102

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26 January 2020

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26 January 2020

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26 January 2020

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