Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2). (Q35958086)

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English	Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).	scientific article

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24 January 2020

Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2) (English)

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24 January 2020

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Plasmodium falciparum

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4

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24 January 2020

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24 January 2020

Sitthivut Charoensutthivarakul

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24 January 2020

Giancarlo Biagini

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24 January 2020

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Ashley J Warman

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Richard K Amewu

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Chandrakala Pidathala

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Alison Mbekeani

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24 January 2020

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Suet C Leung

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24 January 2020

Bénédicte Pacorel

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Olivier Berger

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24 January 2020

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Peter Gibbons

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24 January 2020

W David Hong

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24 January 2020

Raman Sharma

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24 January 2020

Abhishek Srivastava

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24 January 2020

Lee Taylor

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24 January 2020

Alasdair Hill

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Nicholas E Fisher

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24 January 2020

Paul M O'Neill

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24 January 2020

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24 February 2012

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24 January 2020

Journal of Medicinal Chemistry

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24 January 2020

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24 January 2020

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24 January 2020

1844-1857

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24 January 2020

Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

1 reference

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2 October 2017

The state of the art in anti-malarial drug discovery and development

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2 October 2017

A research agenda for malaria eradication: drugs

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2 October 2017

Extended-connectivity fingerprints

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Current trends in ligand-based virtual screening: molecular representations, data mining methods, new application areas, and performance evaluation

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2 October 2017

Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays.

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Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex

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2 October 2017

The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle

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Similarity-based virtual screening using 2D fingerprints

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Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria

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PowerMV: a software environment for molecular viewing, descriptor generation, data analysis and hit evaluation

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XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkey

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12 December 2020

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