A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor (Q35964764)

11 August 2017

A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor (English)

1 reference

Probable insulin-like peptide beta-type 5 CELE_ZK84.6

11 August 2017

Caenorhabditis elegans

0 references

1 reference

GOA release 2020-03-11

author name string

Qing-Xin Hua

1

1 reference

11 August 2017

Satoe H Nakagawa

2

1 reference

11 August 2017

Jill Wilken

3

1 reference

11 August 2017

Rowena R Ramos

4

1 reference

11 August 2017

Wenhua Jia

5

1 reference

11 August 2017

Joseph Bass

6

1 reference

11 August 2017

Michael A Weiss

7

1 reference

11 August 2017

21 March 2003

1 reference

11 August 2017

1 reference

11 August 2017

17

1 reference

11 August 2017

7

1 reference

11 August 2017

826-831

1 reference

daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Structural biology of insulin and IGF1 receptors: implications for drug design

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Genetic pathways that regulate ageing in model organisms

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Congenital insulin resistance associated with a conformational alteration in a conserved beta-sheet in the insulin receptor L1 domain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

The proprotein convertases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Synthesis of proteins by native chemical ligation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

The structure of 2Zn pig insulin crystals at 1.5 A resolution

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Control of C. elegans larval development by neuronal expression of a TGF-beta homolog

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Single chain des-(B30) insulin. Intramolecular crosslinking of insulin by trypsin catalyzed transpeptidation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Hydroxyl group of insulin A19Tyr is essential for receptor binding: studies on (A19Phe)insulin.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Three mutant insulins in man

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196032

Hierarchical protein "un-design": insulin's intrachain disulfide bridge tethers a recognition alpha-helix

24 September 2018

1 reference

12 December 2020

The genetics of aging

1 reference

12 December 2020

Implications of invariant residue LeuB6 in insulin-receptor interactions

1 reference

12 December 2020

Importance of aliphatic side-chain structure at positions 2 and 3 of the insulin A chain in insulin-receptor interactions

1 reference

12 December 2020

Alanine scanning mutagenesis of insulin

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.1058003

1 reference

11 August 2017

1 reference

11 August 2017

1 reference