Targeting the mitogen-activated protein kinase cascade to treat cancer (Q35968411)

11 August 2017

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title

Targeting the mitogen-activated protein kinase cascade to treat cancer (English)

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11 August 2017

Judith S Sebolt-Leopold

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1

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11 August 2017

Roman Herrera

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2

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11 August 2017

language of work or name

English

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publication date

1 December 2004

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11 August 2017

Nature Reviews Cancer

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11 August 2017

4

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11 August 2017

12

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11 August 2017

937-947

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https://scigraph.springernature.com/pub.10.1038/nrc1503

11 August 2017

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cites work

Modelling the molecular circuitry of cancer

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Proliferation, cell cycle and apoptosis in cancer

21 January 2018

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Molecular mechanisms of "detachment-induced apoptosis--Anoikis".

21 January 2018

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Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

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Anchorage-dependent cell cycle progression

21 January 2018

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Integrating the MAP kinase signal into the G1 phase cell cycle machinery

21 January 2018

1 reference

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

1 reference

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

21 January 2018

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Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

21 January 2018

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The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation

21 January 2018

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

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Ras signaling: PP2A puts Ksr and Raf in the right place

21 January 2018

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High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

21 January 2018

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Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

21 January 2018

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Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

21 January 2018

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A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.

21 January 2018

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Molecular interpretation of ERK signal duration by immediate early gene products

21 January 2018

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Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase

21 January 2018

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Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological intervention

21 January 2018

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Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

21 January 2018

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Rsk1 mediates a MEK-MAP kinase cell survival signal

21 January 2018

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

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Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

21 January 2018

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

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Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

21 January 2018

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Anchorage-dependent ERK signaling--mechanisms and consequences

21 January 2018

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Mitogen-activated protein kinases in apoptosis regulation

21 January 2018

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Map kinase signaling pathways and hematologic malignancies

21 January 2018

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MAP kinases in chondrocyte differentiation.

21 January 2018

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Chronic activation of extracellular-signal-regulated protein kinases by phenylephrine is required to elicit a hypertrophic response in cardiac myocytes

21 January 2018

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Targeting RAS signalling pathways in cancer therapy

21 January 2018

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RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

21 January 2018

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Signal transduction from multiple Ras effectors

21 January 2018

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Mutations of the BRAF gene in human cancer

21 January 2018

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RAF/RAS oncogenes and mismatch-repair status

21 January 2018

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B-RAF is a therapeutic target in melanoma

21 January 2018

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BRAF as a potential therapeutic target in melanoma and other malignancies

21 January 2018

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Mechanisms of regulating the Raf kinase family

21 January 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

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Switching on kinases: oncogenic activation of BRAF and the PDGFR family

21 January 2018

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

21 January 2018

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Ordered phosphorylation of p42mapk by MAP kinase kinase

21 January 2018

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

21 January 2018

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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

21 January 2018

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A hot spot for protein kinase inhibitor sensitivity.

21 January 2018

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A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

21 January 2018

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Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

21 January 2018

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Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

21 January 2018

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Structure and regulation of MAPK phosphatases

21 January 2018

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Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1).

21 January 2018

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Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

21 January 2018

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Colorectal tumors frequently express phosphorylated mitogen-activated protein kinase

21 January 2018

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Platelet-activating factor activates mitogen-activated protein kinases, inhibits proliferation, induces differentiation and suppresses the malignant phenotype of human colon carcinoma cells.

21 January 2018

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Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells

21 January 2018

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Enhancement of anchorage-independent growth of human pancreatic carcinoma MIA PaCa-2 cells by signaling from protein kinase C to mitogen-activated protein kinase

21 January 2018

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CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential

21 January 2018

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Notch Signaling and ERK Activation Are Important for the Osteomimetic Properties of Prostate Cancer Bone Metastatic Cell Lines

21 January 2018

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ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours.

21 January 2018

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Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro

21 January 2018

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Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

21 January 2018

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

31 March 2020

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CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

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Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of p44mapk and p42mapk isoforms in the G1 phase and their inactivation at the G1/S transition

31 March 2020

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Molecular regulation of neutrophil apoptosis and potential targets for therapeutic strategy against the inflammatory process

31 March 2020

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Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

31 March 2020

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Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma

31 March 2020

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BRAF Mutation in Papillary Thyroid Carcinoma

31 March 2020

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BAY 43-9006: early clinical data in patients with advanced solid malignancies

31 March 2020

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Transformation of mammalian cells by constitutively active MAP kinase kinase

31 March 2020

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MEK inhibitors: a therapeutic approach to targeting the Ras-MAP kinase pathway in tumors

31 March 2020

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CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)

31 March 2020

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Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

31 March 2020

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The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

31 March 2020

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Hyperexpression of mitogen-activated protein kinase in human breast cancer

31 March 2020

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Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis

31 March 2020

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Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway

31 March 2020

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Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1503

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Dimensions Publication ID

11 August 2017

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