Mechanisms and functional significance of tumour-induced dendritic-cell defects (Q35968465)

11 August 2017

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title

Mechanisms and functional significance of tumour-induced dendritic-cell defects (English)

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11 August 2017

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Dmitry Gabrilovich

1

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11 August 2017

1 December 2004

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Nature Reviews Immunology

11 August 2017

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11 August 2017

4

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11 August 2017

12

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11 August 2017

941-952

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Growth factors, cytokines and dendritic cell development.

11 August 2017

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Notch signaling is necessary but not sufficient for differentiation of dendritic cells.

31 March 2020

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The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells

31 March 2020

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The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells.

31 March 2020

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Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin.

31 March 2020

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Mouse and human dendritic cell subtypes

31 March 2020

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Characterization of a common precursor population for dendritic cells

31 March 2020

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Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

31 March 2020

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Some interfaces of dendritic cell biology

31 March 2020

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Immunobiology of dendritic cells

31 March 2020

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Regulation of T cell immunity by dendritic cells

31 March 2020

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Depressed monocyte polarization and clustering of dendritic cells in patients with head and neck cancer: in vitro restoration of this immunosuppression by thymic hormones

31 March 2020

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Human renal-cell carcinoma tissue contains dendritic cells

31 March 2020

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Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts

31 March 2020

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Altered maturation of peripheral blood dendritic cells in patients with breast cancer.

31 March 2020

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Phenotypic characterisation of the dendritic cell infiltrate in prostate cancer

31 March 2020

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Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma

31 March 2020

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Tumor-infiltrating dendritic cells are defective in their antigen-presenting function and inducible B7 expression in rats

31 March 2020

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Prostate tumor microenvironment alters immune cells and prevents long-term survival in an orthotopic mouse model following flt3-ligand/CD40-ligand immunotherapy

31 March 2020

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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

31 March 2020

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Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance

31 March 2020

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Tumor-induced immune dysfunctions caused by myeloid suppressor cells

31 March 2020

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Immature myeloid cells and cancer-associated immune suppression

31 March 2020

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Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species

31 March 2020

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Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer.

31 March 2020

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Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence.

31 March 2020

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Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells

31 March 2020

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Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

31 March 2020

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Role of immature myeloid Gr-1+ cells in the development of antitumor immunity

31 March 2020

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Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation

31 March 2020

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Ehrlich tumor stimulates extramedullar hematopoiesis in mice without secreting identifiable colony-stimulating factors and without engagement of host T cells

31 March 2020

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Resection of solid tumors reverses T cell defects and restores protective immunity

31 March 2020

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Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species.

31 March 2020

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Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses

31 March 2020

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IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice

31 March 2020

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Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer

31 March 2020

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Surgical removal of primary tumor reverses tumor-induced immunosuppression despite the presence of metastatic disease

31 March 2020

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Tumor Escape from Immune Response: Mechanisms and Targets of Activity

31 March 2020

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Dendritic cells in antitumor immune responses. II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice, are effective antigen carriers in the therapy of established tumors.

31 March 2020

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Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

31 March 2020

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Quantitative analysis of vascular endothelial growth factor in primary breast cancer

31 March 2020

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Angiogenesis and metastasis

31 March 2020

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Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue

31 March 2020

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Vascular endothelial growth factor inhibits maturation of dendritic cells induced by lipopolysaccharide, but not by proinflammatory cytokines

31 March 2020

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Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6.

31 March 2020

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Ex vivo induction of multiple myeloma–specific cytotoxic T lymphocytes

31 March 2020

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IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation.

31 March 2020

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Antibodies to colony-stimulating factors block Lewis lung carcinoma cell stimulation of immune-suppressive bone marrow cells

31 March 2020

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GM-CSF-secreting melanoma vaccines

31 March 2020

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High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells

31 March 2020

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CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity

31 March 2020

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IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages

31 March 2020

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Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10.

31 March 2020

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Interleukin-10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells

31 March 2020

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Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells.

31 March 2020

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Interleukin-10 expressed at early tumour sites induces subsequent generation of CD4(+) T-regulatory cells and systemic collapse of antitumour immunity

31 March 2020

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Structure, organization, and function of glycosphingolipids in membrane

31 March 2020

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Role of tumor-associated gangliosides in cancer progression

31 March 2020

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Gangliosides from human melanoma tumors impair dendritic cell differentiation from monocytes and induce their apoptosis

31 March 2020

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Janus kinases: components of multiple signaling pathways

31 March 2020

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31 March 2020

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JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

31 March 2020

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The STATs of cancer--new molecular targets come of age

31 March 2020

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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

31 March 2020

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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

31 March 2020

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A critical role for Stat3 signaling in immune tolerance

31 March 2020

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The synergy between stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF): molecular basis and clinical relevance

31 March 2020

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Control of myeloid differentiation and survival by Stats

31 March 2020

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Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system

31 March 2020

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Dendritic cell development and survival require distinct NF-kappaB subunits

31 March 2020

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Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER.

31 March 2020

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Expression of relB is required for the development of thymic medulla and dendritic cells

31 March 2020

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Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB

31 March 2020

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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

31 March 2020

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Prospective isolation of human clonogenic common myeloid progenitors

31 March 2020

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IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals

31 March 2020

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STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1498

1 reference

11 August 2017

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PubMed ID

15573129