The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. (Q35973393)

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24 February 2020

title

The RNA-editing enzyme ADAR1 controls innate immune responses to RNA (English)

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9

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Sarah L McGlasson

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24 February 2020

Christoffer Nellåker

7

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Cornelia Vesely

8

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Michael F Jantsch

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Ian R. Adams

13

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Marie Öhman

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24 February 2020

Mary A O'Connell

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author name string

Niamh M Mannion

1

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24 February 2020

Sam M Greenwood

2

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24 February 2020

Robert Young

3

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24 February 2020

James Brindle

5

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24 February 2020

David Read

6

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Paul J McLaughlin

10

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Julia Dorin

12

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A D J Scadden

14

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24 February 2020

Liam P Keegan

16

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publication date

13 November 2014

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24 February 2020

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24 February 2020

volume

9

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issue

4

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24 February 2020

page(s)

1482-1494

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Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs

24 February 2020

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Conflict RNA modification, host-parasite co-evolution, and the origins of DNA and DNA-binding proteins1.

2 October 2017

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Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

2 October 2017

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Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

2 October 2017

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A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

2 October 2017

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Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

2 October 2017

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Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing

2 October 2017

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The JAK-STAT pathway at twenty

2 October 2017

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Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome

2 October 2017

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Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

2 October 2017

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Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

2 October 2017

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Structural Insights into RNA Recognition by RIG-I

2 October 2017

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Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects.

2 October 2017

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Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

2 October 2017

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Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

2 October 2017

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RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

2 October 2017

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Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

2 October 2017

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Pattern recognition receptors and inflammation

2 October 2017

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Editing independent effects of ADARs on the miRNA/siRNA pathways

2 October 2017

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ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

2 October 2017

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A brilliant disguise for self RNA: 5'-end and internal modifications of primary transcripts suppress elements of innate immunity

2 October 2017

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Genome-wide transcription and the implications for genomic organization

2 October 2017

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Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

2 October 2017

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2 October 2017

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Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

2 October 2017

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Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1

2 October 2017

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Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene

2 October 2017

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Elevated activity of the large form of ADAR1 in vivo: Very efficient RNA editing occurs in the cytoplasm

2 October 2017

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Dynamic association of RNA-editing enzymes with the nucleolus

2 October 2017

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RNA editing by base deamination: more enzymes, more targets, new mysteries

2 October 2017

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Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2

2 October 2017

1 reference

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Structure-function analysis of the Z-DNA-binding domain Zalpha of dsRNA adenosine deaminase type I reveals similarity to the (alpha + beta) family of helix-turn-helix proteins

2 October 2017

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Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.

2 October 2017

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Double-stranded RNAs containing multiple IU pairs are sufficient to suppress interferon induction and apoptosis

11 July 2018

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Gain of function mutations in p53.

11 July 2018

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A type I interferon signature identifies bilateral striatal necrosis due to mutations in ADAR1.

11 July 2018

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The food contaminant deoxynivalenol activates the mitogen activated protein kinases in the intestine: interest of ex vivo models as an alternative to in vivo experiments

24 September 2018

1 reference

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Two novel mutations and evidence for haploinsufficiency of the ADAR gene in dyschromatosis symmetrica hereditaria

24 September 2018

1 reference

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The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage

24 September 2018

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10.1016/J.CELREP.2014.10.041

24 September 2018

Identifiers

DOI

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