Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection (Q35992186)

11 August 2017

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection (English)

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Mycobacterium tuberculosis

11 August 2017

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17

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13

Nico Ghilardi

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Egídio Torrado

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Egidio Torrado

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Graeme Meintjes

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Graeme Meintjes

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Susan L. Swain

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object named as

Susan L Swain

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11 August 2017

Jeffrey J Fountain

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Mingfeng Liao

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Michael Tighe

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William W Reiley

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Rachel P Lai

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John E Pearl

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Xinchun Chen

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Daniel E Zak

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Ethan G Thompson

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Alan Aderem

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Alejandra Solache

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K Kai McKinstry

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Tara M Strutt

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Andrea M Cooper

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language of work or name

English

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publication date

17 August 2015

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Journal of Experimental Medicine

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212

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9

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1449-1463

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describes a project that uses

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ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4548054/fullTextXML

inferred from PubMed Central ID database lookup

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The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology

2 October 2017

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2 October 2017

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2 October 2017

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CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

2 October 2017

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Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

2 October 2017

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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

2 October 2017

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Genetic dissection of immunity to mycobacteria: the human model

2 October 2017

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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

2 October 2017

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Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation

2 October 2017

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11 July 2018

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Control of chronic mycobacterium tuberculosis infection by CD4 KLRG1- IL-2-secreting central memory cells

11 July 2018

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IL-27 limits IL-2 production during Th1 differentiation.

11 July 2018

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Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells

11 July 2018

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IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548054

Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548054

Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.

23 September 2018

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Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548054

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

23 September 2018

1 reference

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PPD induced in vitro interferon gamma production is not a reliable correlate of protection against Mycobacterium tuberculosis

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20141520

IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice

21 January 2018

1 reference

12 December 2020

The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis

1 reference

12 December 2020

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

1 reference

12 December 2020

Tuberculosis in patients with human immunodeficiency virus infection

1 reference

12 December 2020

IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20141520

1 reference

11 August 2017

1 reference

11 August 2017

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