Regulation of physiologic actions of LRRK2: focus on autophagy (Q35997636)

11 August 2017

Regulation of physiologic actions of LRRK2: focus on autophagy (English)

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11 August 2017

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Andrew Ferree

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11 August 2017

Maria Guillily

2

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11 August 2017

Hu Li

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11 August 2017

Katelyn Smith

4

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11 August 2017

Aki Takashima

5

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11 August 2017

Rachel Squillace

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11 August 2017

Manfred Weigele

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11 August 2017

James J Collins

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11 August 2017

Benjamin Wolozin

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11 August 2017

23 December 2011

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Neurodegenerative Diseases

11 August 2017

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11 August 2017

10

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11 August 2017

1-4

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11 August 2017

238-241

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Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens

11 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

GTPase activity plays a key role in the pathobiology of LRRK2.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3363354

2 October 2017

Identifiers

DOI

10.1159/000332599

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11 August 2017

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11 August 2017

PubMed publication ID

22204929

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