An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. (Q35998604)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22496420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I (English)

1 reference

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28 January 2020

3

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28 January 2020

Johannes Elferich

4

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28 January 2020

1

Jimmy D Dikeakos

1 reference

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28 January 2020

author name string

Laurel Thomas

2

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28 January 2020

Ujwal Shinde

5

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28 January 2020

Gary Thomas

6

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28 January 2020

publication date

11 April 2012

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Molecular Biology of the Cell

28 January 2020

published in

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28 January 2020

volume

23

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28 January 2020

page(s)

2184-2197

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28 January 2020

issue

11

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HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

28 January 2020

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Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action

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2 October 2017

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HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication

2 October 2017

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PACS-1 mediates phosphorylation-dependent ciliary trafficking of the cyclic-nucleotide-gated channel in olfactory sensory neurons

2 October 2017

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2 October 2017

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At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis

2 October 2017

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Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis

2 October 2017

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HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells

2 October 2017

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2 October 2017

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The subcellular distribution of calnexin is mediated by PACS-2

2 October 2017

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SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking.

2 October 2017

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HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.

2 October 2017

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Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit

2 October 2017

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HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

2 October 2017

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A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking

2 October 2017

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The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner

2 October 2017

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2 October 2017

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PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis

2 October 2017

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Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

2 October 2017

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HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway

2 October 2017

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Proline 78 is crucial for human immunodeficiency virus type 1 Nef to down-regulate class I human leukocyte antigen

2 October 2017

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Live and let die: Nef functions beyond HIV replication

2 October 2017

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2 October 2017

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2 October 2017

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PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.

2 October 2017

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2 October 2017

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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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23 September 2018

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23 September 2018

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23 September 2018

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23 September 2018

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PubMed

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12 December 2020

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Identifiers

DOI

10.1091/MBC.E11-11-0928

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28 January 2020

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28 January 2020

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