Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action (Q33655043)

28 July 2017

title

Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action (English)

1 reference

28 July 2017

Matthew D Wortman

8

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Shinya Suzu

object named as

Shinya Suzu

16

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Angela Gronenborn

object named as

Angela M Gronenborn

17

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Thomas E Smithgall

18

object named as

Thomas E Smithgall

1 reference

28 July 2017

1

Jimmy D Dikeakos

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28 July 2017

Katelyn M Atkins

2

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28 July 2017

Laurel Thomas

3

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28 July 2017

Lori Emert-Sedlak

4

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28 July 2017

In-Ja L Byeon

5

1 reference

28 July 2017

Jinwon Jung

6

1 reference

28 July 2017

Jinwoo Ahn

7

1 reference

28 July 2017

Ben Kukull

9

1 reference

28 July 2017

Masumichi Saito

10

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28 July 2017

Hirokazu Koizumi

11

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28 July 2017

Danielle M Williamson

12

1 reference

28 July 2017

Masateru Hiyoshi

13

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28 July 2017

Eric Barklis

14

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28 July 2017

Masafumi Takiguchi

15

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28 July 2017

Gary Thomas

19

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28 July 2017

publication date

11 August 2010

1 reference

Molecular Biology of the Cell

28 July 2017

published in

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28 July 2017

volume

21

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28 July 2017

issue

19

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28 July 2017

page(s)

3279-3292

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Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

28 July 2017

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21 June 2018

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21 June 2018

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HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.

21 June 2018

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21 June 2018

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21 June 2018

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HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

21 June 2018

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Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor

21 June 2018

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Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor.

21 June 2018

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HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction

21 June 2018

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The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner

21 June 2018

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PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis

21 June 2018

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HIV-1 Nef interferes with M-CSF receptor signaling through Hck activation and inhibits M-CSF bioactivities.

21 June 2018

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HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

21 June 2018

1 reference

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Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase

21 June 2018

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HIV Nef-mediated Major Histocompatibility Complex Class I Down-Modulation Is Independent of Arf6 Activity

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane

21 June 2018

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Live and let die: Nef functions beyond HIV replication

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

1 reference

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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

21 June 2018

1 reference

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Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease

21 June 2018

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The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

21 June 2018

1 reference

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21 June 2018

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21 June 2018

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Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

21 June 2018

1 reference

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A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

21 June 2018

1 reference

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Involvement of Golgi-associated Lyn tyrosine kinase in the translocation of annexin II to the endoplasmic reticulum under oxidative stress.

21 June 2018

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HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947465

HIV-1 Nef disrupts antigen presentation early in the secretory pathway

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20702582

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HIV-1 Nef induces a Rab11-dependent routing of endocytosed immune costimulatory proteins CD80 and CD86 to the Golgi

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20702582

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T cell dynamics in HIV-1 infection

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20702582

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1091/MBC.E10-05-0470

1 reference

28 July 2017

1 reference

28 July 2017

1 reference