Origins of leukaemia in children with Down syndrome (Q35998756)

11 August 2017

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title

Origins of leukaemia in children with Down syndrome (English)

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11 August 2017

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Johann K Hitzler

1

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PubMed ID

15630411

11 August 2017

Alvin Zipursky

series ordinal

2

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PubMed ID

15630411

11 August 2017

language of work or name

English

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publication date

1 January 2005

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11 August 2017

Nature Reviews Cancer

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11 August 2017

5

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11 August 2017

11-20

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11 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrc1525

11 August 2017

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cites work

Down's syndrome and leukemia: epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis

1 reference

A tumor profile in Down syndrome.

21 January 2018

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Risks of leukaemia and solid tumours in individuals with Down's syndrome.

21 January 2018

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Pattern of malignant disorders in individuals with Down's syndrome.

21 January 2018

1 reference

Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group

21 January 2018

1 reference

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

21 January 2018

1 reference

Myelodysplasia and acute megakaryoblastic leukemia in Down's syndrome

21 January 2018

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Transient leukaemia--a benign form of leukaemia in newborn infants with trisomy 21.

21 January 2018

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Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome

21 January 2018

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Transient myeloproliferative disorder, a disorder with too few data and many unanswered questions: does it contain an important piece of the puzzle to understanding hematopoiesis and acute myelogenous leukemia?

21 January 2018

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Transient leukemoid disorder in a newborn with Down syndrome followed 19 months later by an acute myeloid leukemia: demonstration of the same structural change in both instances with clonal evolution

21 January 2018

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Acute megakaryoblastic leukemia after transient myeloproliferative disorder with clonal karyotype evolution in a phenotypically normal neonate

21 January 2018

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Natural history of GATA1 mutations in Down syndrome.

21 January 2018

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Transcriptional regulation of erythropoiesis: an affair involving multiple partners

21 January 2018

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FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation

21 January 2018

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Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

21 January 2018

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Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia

21 January 2018

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The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages

21 January 2018

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 January 2018

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

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RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation

21 January 2018

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Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

21 January 2018

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The erythroid-specific transcription factor Eryf1: a new finger protein

21 January 2018

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Megakaryocytic and erythrocytic lineages share specific transcription factors

21 January 2018

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Essential and instructive roles of GATA factors in eosinophil development

21 January 2018

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Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo

21 January 2018

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GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant

21 January 2018

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Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1

21 January 2018

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A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development

21 January 2018

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Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome

21 January 2018

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Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1(low) mice).

21 January 2018

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Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1

21 January 2018

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Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation

21 January 2018

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X-linked thrombocytopenia caused by a novel mutation of GATA-1

21 January 2018

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X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction

21 January 2018

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Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21

21 January 2018

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GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome

21 January 2018

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Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome

21 January 2018

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The GATA1 mutation in an adult patient with acute megakaryoblastic leukemia not accompanying Down syndrome.

21 January 2018

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Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder

21 January 2018

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GATA-1-mediated proliferation arrest during erythroid maturation.

21 January 2018

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Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker.

21 January 2018

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In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis

21 January 2018

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Core-binding factors in haematopoiesis and leukaemia

21 January 2018

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

21 January 2018

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

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Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis

21 January 2018

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21 January 2018

Focus on acute leukemias

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Leukaemia -- a developmental perspective

21 January 2018

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The DNA sequence of human chromosome 21

21 January 2018

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Chromosome 21 and down syndrome: from genomics to pathophysiology

21 January 2018

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A gene expression map of human chromosome 21 orthologues in the mouse

21 January 2018

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Human chromosome 21 gene expression atlas in the mouse.

21 January 2018

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Down syndrome and mouse models.

21 January 2018

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21 January 2018

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Increased age at diagnosis has a significantly negative effect on outcome in children with Down syndrome and acute myeloid leukemia: a report from the Children's Cancer Group Study 2891.

21 January 2018

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Origins of chromosome translocations in childhood leukaemia

21 January 2018

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A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction

21 January 2018

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A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases.

21 January 2018

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Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages

21 January 2018

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Epidemiology of leukemia in children with Down syndrome

21 January 2018

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Clonal hematologic disorders in Down syndrome. A review.

31 March 2020

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Leukemia in Down syndrome: a review

31 March 2020

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Incidence and treatment of potentially lethal diseases in transient leukemia of Down syndrome: Pediatric Oncology Group Study

31 March 2020

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Life-threatening complications of transient abnormal myelopoiesis in neonates with Down syndrome

31 March 2020

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Erythroblastic and/or megakaryoblastic leukemia in Down syndrome: treatment with low-dose arabinosyl cytosine

31 March 2020

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Hydrops fetalis and neonatal leukemia in Down syndrome

31 March 2020

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Neonatal platelet function.

31 March 2020

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Trisomy 8 as a secondary genetic change in acute megakaryoblastic leukemia associated with Down's syndrome

31 March 2020

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Ultrastructural studies of the megakaryoblastic leukemias of Down syndrome

31 March 2020

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Ultrastructural and ultracytochemical differences between transient myeloproliferative disorder and megakaryoblastic leukaemia in Down's syndrome

31 March 2020

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Leukemic blasts with markers of four cell lineages in Down's syndrome ("megakaryoblastic leukemia")

31 March 2020

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Expression of erythroid-specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome

31 March 2020

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Ki-1+ large-cell anaplastic lymphoma after Ewing sarcoma

31 March 2020

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GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts

31 March 2020

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Molecular control of megakaryopoiesis and thrombopoiesis

31 March 2020

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GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia

31 March 2020

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Down syndrome, drug metabolism and chromosome 21.

31 March 2020

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The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines

31 March 2020

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Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis

31 March 2020

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Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome

31 March 2020

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Distinct gene signatures of transient and acute megakaryoblastic leukemia in Down syndrome

31 March 2020

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Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor

31 March 2020

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Down syndrome phenotypes: the consequences of chromosomal imbalance

31 March 2020

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Mouse trisomy 16: an animal model of human trisomy 21 (Down syndrome)

31 March 2020

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Down syndrome and acute myeloid leukemia: the paradox of increased risk for leukemia and heightened sensitivity to chemotherapy

31 March 2020

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The treatment of children with acute megakaryoblastic leukemia who have Down syndrome

31 March 2020

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Immunohistochemical study on transforming growth factor-beta1 expression in liver fibrosis of Down's syndrome with transient abnormal myelopoiesis

31 March 2020

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High expression of platelet-derived growth factor and transforming growth factor-beta 1 in blast cells from patients with Down Syndrome suffering from transient myeloproliferative disorder and organ fibrosis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1525

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11 August 2017

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PubMed ID

15630411