Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis (Q36006369)

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19 January 2020

title

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis (English)

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19 January 2020

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7

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19 January 2020

author name string

Maria Mastrogiannaki

1

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19 January 2020

Pavle Matak

2

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19 January 2020

Jacques R R Mathieu

3

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19 January 2020

Stéphanie Delga

4

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19 January 2020

Patrick Mayeux

5

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19 January 2020

Sophie Vaulont

6

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19 January 2020

publication date

29 December 2011

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19 January 2020

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19 January 2020

volume

97

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19 January 2020

issue

6

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19 January 2020

page(s)

827-834

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Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression

19 January 2020

cites work

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Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

2 October 2017

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Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

2 October 2017

1 reference

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Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling

2 October 2017

1 reference

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Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project

2 October 2017

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Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

2 October 2017

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Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis

2 October 2017

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Hepcidin in beta-thalassemia

2 October 2017

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Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia.

2 October 2017

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Hypoxic regulation of erythropoiesis and iron metabolism

2 October 2017

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Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors

2 October 2017

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The role of hepcidin in iron metabolism

2 October 2017

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Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

2 October 2017

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Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

2 October 2017

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Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

2 October 2017

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Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

2 October 2017

1 reference

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Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli.

2 October 2017

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Nonrenal regulation of EPO synthesis

2 October 2017

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The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

2 October 2017

1 reference

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Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

2 October 2017

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The serine protease TMPRSS6 is required to sense iron deficiency

2 October 2017

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Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha

2 October 2017

1 reference

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2-Oxoglutarate-dependent oxygenases control hepcidin gene expression

2 October 2017

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Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

2 October 2017

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Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

2 October 2017

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Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

2 October 2017

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ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3.

2 October 2017

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Suppression of hepcidin during anemia requires erythropoietic activity

2 October 2017

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Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

2 October 2017

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Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins.

2 October 2017

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

2 October 2017

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2 October 2017

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2 October 2017

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

2 October 2017

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HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

2 October 2017

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Hepcidin downregulation by repeated bleeding is not mediated by soluble hemojuvelin

11 July 2018

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Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis.

11 July 2018

1 reference

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High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

23 September 2018

1 reference

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Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression

23 September 2018

1 reference

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Thiazole orange: a new dye for reticulocyte analysis

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22207682

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3324/HAEMATOL.2011.056119

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22207682%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22207682%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

22207682

1 reference