The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors. (Q36020990)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26098773%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors (English)

1 reference

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17 February 2020

5

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17 February 2020

Olivier Sordet

7

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17 February 2020

author name string

Audrey Delmas

1

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17 February 2020

Julia Cherier

2

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17 February 2020

Magdalena Pohorecka

3

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17 February 2020

Claire Medale-Giamarchi

4

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17 February 2020

Anne Casanova

6

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17 February 2020

Laurence Lamant

8

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17 February 2020

Ariel Savina

9

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17 February 2020

Anne Pradines

10

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17 February 2020

Gilles Favre

11

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17 February 2020

language of work or name

English

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publication date

1 June 2015

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17 February 2020

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17 February 2020

volume

6

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17 February 2020

issue

17

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17 February 2020

page(s)

15250-15264

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B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells.

17 February 2020

cites work

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PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation

2 October 2017

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Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

2 October 2017

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Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway

2 October 2017

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RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics

2 October 2017

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Downregulation of Noxa by RAF/MEK inhibition counteracts cell death response in mutant B-RAF melanoma cells

2 October 2017

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Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas

2 October 2017

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RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis

2 October 2017

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RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage

2 October 2017

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CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms

2 October 2017

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BRAFV600E negatively regulates the AKT pathway in melanoma cell lines

2 October 2017

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Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma

2 October 2017

1 reference

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Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

2 October 2017

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RhoB mediates antitumor synergy of combined ixabepilone and sunitinib in human ovarian serous cancer

2 October 2017

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Adaptive upregulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells

2 October 2017

1 reference

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Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells

2 October 2017

1 reference

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BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study

2 October 2017

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

2 October 2017

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Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

2 October 2017

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PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

2 October 2017

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

2 October 2017

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

2 October 2017

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Induction of small G protein RhoB by non-genotoxic stress inhibits apoptosis and activates NF-κB.

2 October 2017

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JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative

2 October 2017

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Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma

2 October 2017

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Rho GTPase function in tumorigenesis

2 October 2017

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RhoE enhances multidrug resistance of gastric cancer cells by suppressing Bax.

2 October 2017

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B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival

2 October 2017

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2 October 2017

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B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization

2 October 2017

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Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells

2 October 2017

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Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

2 October 2017

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Loss of RhoB expression in human lung cancer progression.

2 October 2017

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EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation

2 October 2017

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RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development

2 October 2017

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BRAF as a potential therapeutic target in melanoma and other malignancies

2 October 2017

1 reference

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Mutations of the BRAF gene in human cancer

2 October 2017

1 reference

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RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558149

Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558149

rhoB encoding a UV-inducible Ras-related small GTP-binding protein is regulated by GTPases of the Rho family and independent of JNK, ERK, and p38 MAP kinase

2 October 2017

1 reference

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Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558149

RhoB mRNA is stabilized by HuR after UV light

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558149

11 July 2018

1 reference

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RhoB determines tumor aggressiveness in a murine EGFRL858R-induced adenocarcinoma model and is a potential prognostic biomarker for Lepidic lung cancer.

11 July 2018

1 reference

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RhoB promotes cancer initiation by protecting keratinocytes from UVB-induced apoptosis but limits tumor aggressiveness.

23 September 2018

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Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618.

23 September 2018

1 reference

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Increase of RhoB in gamma-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells.

23 September 2018

1 reference

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Loss of RhoB expression promotes migration and invasion of human bronchial cells via activation of AKT1.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558149

RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558149

Cloning of the human RHOB gene promoter: characterization of a VNTR sequence that affects transcriptional activity

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558149

The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26098773

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.3888

1 reference

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release_i5o4jo4ocvfwrpw2hkzsta4sle

17 February 2020

Fatcat ID

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Fatcat

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mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26098773%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

26098773

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26098773%20AND%20SRC:MED&resulttype=core&format=json