Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells (Q36024406)

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English	Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1 reference

based on heuristic

inferred from title

colon adenocarcinoma

1 reference

based on heuristic

inferred from title

author name string

Xi Emily Zheng

1

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Europe PubMed Central

PMC publication ID

11 August 2017

Zhican Wang

2

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Europe PubMed Central

PMC publication ID

11 August 2017

Michael Z Liao

3

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Europe PubMed Central

PMC publication ID

11 August 2017

Yvonne S Lin

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Margaret C Shuhart

5

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Europe PubMed Central

PMC publication ID

11 August 2017

Erin G Schuetz

6

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Europe PubMed Central

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11 August 2017

Kenneth E Thummel

7

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Europe PubMed Central

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11 August 2017

language of work or name

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publication date

4 May 2012

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Europe PubMed Central

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11 August 2017

Biochemical Pharmacology

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Europe PubMed Central

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11 August 2017

84

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Europe PubMed Central

PMC publication ID

11 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

391-401

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Europe PubMed Central

PMC publication ID

11 August 2017

Simultaneous measurement of plasma vitamin D(3) metabolites, including 4β,25-dihydroxyvitamin D(3), using liquid chromatography-tandem mass spectrometry

1 reference

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Influence of dietary substances on intestinal drug metabolism and transport.

1 reference

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2 October 2017

Grapefruit juice enhances the exposure to oral oxycodone

1 reference

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2 October 2017

Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption

1 reference

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2 October 2017

The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

The effect of differentiation on 1,25 dihydroxyvitamin D-mediated gene expression in the enterocyte-like cell line, Caco-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Regulation of intestinal calcium transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry

1 reference

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2 October 2017

Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine

1 reference

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2 October 2017

Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodefic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene

1 reference

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2 October 2017

Anti-epileptic medication and bone health

1 reference

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2 October 2017

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women

1 reference

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2 October 2017

Resurrection of vitamin D deficiency and rickets

1 reference

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2 October 2017

Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

1,25-Dihydroxyvitamin D and 25-hydroxyvitamin D--mediated regulation of TRPV6 (a putative epithelial calcium channel) mRNA expression in Caco-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Epilepsy and bone health in adults

1 reference

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2 October 2017

Application of 4-(4-nitrophenyl)-1,2,4-triazoline-3,5-dione to analysis of 25-hydroxyvitamin D3 in human plasma by liquid chromatography/electron capture atmospheric pressure chemical ionization-mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Increased vitamin D receptor level enhances 1,25-dihydroxyvitamin D3-mediated gene expression and calcium transport in Caco-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Skeletal responsiveness to endogenous parathyroid hormone in postmenopausal osteoporosis

1 reference

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2 October 2017

Clinical Pharmacokinetics of Rifampicin

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

2 October 2017

Grapefruit juice interaction with oral budesonide: equal effect on immediate-release and delayed-release formulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

11 July 2018

Co-administration of grapefruit juice increases bioavailability of tacrolimus in liver transplant patients: a prospective study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

23 September 2018

Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372629

23 September 2018

The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.

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23 September 2018

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23 September 2018

Metabolism of 20-epimer of 1alpha,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats

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23 September 2018

Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR.

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23 September 2018

Relationship between free and total 1,25-dihydroxyvitamin D in conditions of modified binding

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23 September 2018

Interaction between grapefruit juice and midazolam in humans*

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23 September 2018

Rifampicin and vitamin D metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22562045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased serum ionized calcium and normal vitamin D metabolite levels with anticonvulsant drug treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/22562045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/22562045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the 1,25-dihydroxyvitamin D3-24-hydroxylase gene in rat intestine: response to calcium, vitamin D3 and calcitriol administration in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22562045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential time course of induction of 1alpha,25-dihydroxyvitamin D3-24-hydroxylase mRNA expression in rats by 1alpha,25-dihydroxyvitamin D3 and its analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22562045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum concentrations of the antimycobacterial drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22562045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of genes involved in calcium absorption in human duodenum

1 reference

https://pubmed.ncbi.nlm.nih.gov/22562045

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BCP.2012.04.019

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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