Bleomycins: towards better therapeutics (Q36026763)

11 August 2017

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title

Bleomycins: towards better therapeutics (English)

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11 August 2017

2

JoAnne Stubbe

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11 August 2017

Jingyang Chen

1

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11 August 2017

language of work or name

English

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publication date

1 February 2005

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11 August 2017

published in

Nature Reviews Cancer

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11 August 2017

volume

5

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11 August 2017

issue

2

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11 August 2017

page(s)

102-112

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Curing metastatic testicular cancer

11 August 2017

cites work

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Bleomycin-induced pneumonitis

21 January 2018

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Transfer of oxygen from an artificial protease to peptide carbon during proteolysis

21 January 2018

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RNA degradation by bleomycin, a naturally occurring bioconjugate

21 January 2018

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Bleomycin: new perspectives on the mechanism of action

21 January 2018

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Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin

21 January 2018

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Binding of bleomycin to DNA: intercalation of the bithiazole rings

21 January 2018

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Metallobleomycin-mediated cleavage of DNA not involving a threading-intercalation mechanism

21 January 2018

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The ratio of single- to double-strand DNA breaks and their absolute values determine cell death pathway

21 January 2018

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Analogues of bleomycin: synthesis of conformationally rigid methylvalerates

21 January 2018

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Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library

21 January 2018

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DNA double-strand breaks and alkali-labile bonds produced by bleomycin

21 January 2018

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Sequence-specific double-strand cleavage of DNA by Fe-bleomycin. 2. Mechanism and dynamics

21 January 2018

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A model of the structure of HOO-Co.bleomycin bound to d(CCAGTACTGG): recognition at the d(GpT) site and implications for double-stranded DNA cleavage.

21 January 2018

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Bleomycin causes release of nucleosomes from chromatin and chromosomes

21 January 2018

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Biochemical and cytological studies of bleomycin actions on chromatin and chromosomes

21 January 2018

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Genetic toxicology of bleomycin

21 January 2018

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Detection of DNA Double-strand Breaks through the Cell Cycle after Exposure to X-rays, Bleomycin, Etoposide and125IdUrd

21 January 2018

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3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends

21 January 2018

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Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3'-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation.

21 January 2018

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APE1 is the major 3'-phosphoglycolate activity in human cell extracts

21 January 2018

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Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

21 January 2018

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Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

21 January 2018

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Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

21 January 2018

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Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity

21 January 2018

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Plant sterols as selective DNA polymerase beta lyase inhibitors and potentiators of bleomycin cytotoxicity

21 January 2018

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Regulation and mechanisms of mammalian double-strand break repair

21 January 2018

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

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Single Base-Pair Deletions Induced by Bleomycin at Potential Double-strand Cleavage Sites in the aprt Gene of Stationary Phase Chinese Hamster Ovary D422 Cells

21 January 2018

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Molecular characterization of mutations at the hprt locus in V79 Chinese hamster cells induced by bleomycin in the presence of inhibitors of DNA repair

21 January 2018

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Influence of chromatin structure on bleomycin-DNA interactions at base pair resolution in the human beta-globin gene cluster

21 January 2018

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Increased sensitivity to chromatid aberration induction by bleomycin and neocarzinostatin results from alterations in a DNA damage response pathway

21 January 2018

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Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

21 January 2018

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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

21 January 2018

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Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

21 January 2018

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In vivo evolution of tumour cells after the generation of double-strand DNA breaks

21 January 2018

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Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation

21 January 2018

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Identification of a Plasma Membrane Protein That Specifically Binds Bleomycin

21 January 2018

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Internalisation of the bleomycin molecules responsible for bleomycin toxicity: a receptor-mediated endocytosis mechanism

21 January 2018

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Isolation and characterization of Saccharomyces cerevisiae mutants with enhanced resistance to the anticancer drug bleomycin

21 January 2018

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A genome-wide screen in Saccharomyces cerevisiae reveals altered transport as a mechanism of resistance to the anticancer drug bleomycin

21 January 2018

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Characterization of a transport and detoxification pathway for the antitumour drug bleomycin in Saccharomyces cerevisiae

21 January 2018

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Identification of transcriptome profiles for the DNA-damaging agents bleomycin and hydrogen peroxide in L5178Y mouse lymphoma cells

21 January 2018

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Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

21 January 2018

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Molecular monitoring of bleomycin-induced pulmonary fibrosis by cDNA microarray-based gene expression profiling

21 January 2018

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Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

21 January 2018

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Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity

21 January 2018

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Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase family

21 January 2018

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Total synthesis of deamido bleomycin a(2), the major catabolite of the antitumor agent bleomycin

21 January 2018

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Cellular resistance to bleomycin in Saccharomyces cerevisiae is not affected by changes in bleomycin hydrolase levels

21 January 2018

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The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase

21 January 2018

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An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.

21 January 2018

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BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation

21 January 2018

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Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation

21 January 2018

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Remarkable structural similarities between diverse glycosyltransferases

21 January 2018

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Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

21 January 2018

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Site-specific cleavage of RNA by Fe(II).bleomycin

21 January 2018

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Fe.bleomycin as a probe of RNA conformation

21 January 2018

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RNA cleavage and inhibition of protein synthesis by bleomycin

21 January 2018

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The mechanism of non-homologous end-joining: a synopsis of synapsis

21 January 2018

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The 1.6-A crystal structure of the copper(II)-bound bleomycin complexed with the bleomycin-binding protein from bleomycin-producing Streptomyces verticillus

21 January 2018

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Structure of bleomycin-induced DNA double-strand breaks: predominance of blunt ends and single-base 5' extensions

21 January 2018

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The DNA damage response: putting checkpoints in perspective

21 January 2018

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Copper-dependent cleavage of DNA by bleomycin

21 January 2018

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Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.

21 January 2018

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The importance of bleomycin in combination chemotherapy for good-prognosis germ cell carcinoma. Australasian Germ Cell Trial Group

21 January 2018

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Lipid peroxidation by bleomycin-iron complexes in vitro

31 March 2020

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Bleomycin-induced DNA-strand damage in isolated male germ cells

31 March 2020

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Excision of C-4'-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase beta

31 March 2020

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Mispyric Acid, a New Monocyclic Triterpenoid with a Novel Skeleton fromMischocarpus pyriformisthat Inhibits DNA Polymerase β

31 March 2020

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Mutation screenig of bleomycin-induced V79 Chinese hamster hprt mutants using multiplex polymerse chain reaction

31 March 2020

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Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma-irradiation and bleomycin is p53-independent

31 March 2020

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Cytotoxic and antitumor properties of bleomycin and several of its metal complexes

31 March 2020

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Comparative subcellular distribution of the copper complexes of bleomycin-A2 and deglycobleomycin-A2

31 March 2020

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Identifying fibrosis susceptibility genes in two strains of inbred mice

31 March 2020

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A bleomycin-inactivating enzyme in mouse liver

31 March 2020

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Single-strand and double-strand deoxyribonucleic acid breaks produced by several bleomycin analogs

31 March 2020

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Severe bleomycin-induced pneumonitis. Clinical features and response to corticosteroids

31 March 2020

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Monoclonal antibody mediated intracellular targeting of tallysomycin S(10b)

31 March 2020

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Mechanism of bleomycin: evidence for a rate-determining 4'-hydrogen abstraction from poly(dA-dU) associated with the formation of both free base and base propenal

31 March 2020

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Copper(I)-bleomycin: structurally unique complex that mediates oxidative DNA strand scission

31 March 2020

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Studies of metallobleomycins by electronic spectroscopy, electron spin resonance spectroscopy, and potentiometric titration

31 March 2020

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRC1547

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11 August 2017

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