Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease (Q36044265)

11 August 2017

Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease (English)

1 reference

11 August 2017

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James L Searcy

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11 August 2017

Jeremiah T Phelps

2

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11 August 2017

Tristano Pancani

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11 August 2017

Inga Kadish

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11 August 2017

Jelena Popovic

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11 August 2017

Katie L Anderson

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11 August 2017

Tina L Beckett

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11 August 2017

Michael P Murphy

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11 August 2017

Kuey-Chu Chen

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11 August 2017

Eric M Blalock

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11 August 2017

Philip W Landfield

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11 August 2017

Nada M Porter

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11 August 2017

Olivier Thibault

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11 August 2017

1 January 2012

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Journal of Alzheimer's Disease

11 August 2017

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11 August 2017

30

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4

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943-961

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describes a project that uses

11 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3378773/fullTextXML

inferred from PubMed Central ID database lookup

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2 October 2017

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2 October 2017

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DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice

2 October 2017

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The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice

2 October 2017

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2 October 2017

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2 October 2017

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Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle

2 October 2017

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2 October 2017

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Effects of long-term pioglitazone treatment on peripheral and central markers of aging

2 October 2017

1 reference

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Rosiglitazone and cognitive stability in older individuals with type 2 diabetes and mild cognitive impairment

2 October 2017

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Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

2 October 2017

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Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model

2 October 2017

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17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention

2 October 2017

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Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice

2 October 2017

1 reference

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Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.

2 October 2017

1 reference

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A comparison of glycemic control, water retention, and musculoskeletal effects of balaglitazone and pioglitazone in diet-induced obese rats

2 October 2017

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Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons

2 October 2017

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Estradiol reverses a calcium-related biomarker of brain aging in female rats

2 October 2017

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Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment

2 October 2017

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2 October 2017

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The early and ongoing experience with the cholesterol-fed rabbit as a model of Alzheimer's disease: the old, the new and the pilot.

2 October 2017

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Estrogen and hippocampal plasticity in rodent models

2 October 2017

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2 October 2017

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The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications

2 October 2017

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iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease

2 October 2017

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2 October 2017

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To gate or not to gate: are the delta subunits in the glutamate receptor family functional ion channels?

2 October 2017

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Glutamate receptor-mediated restoration of experience-dependent place field expansion plasticity in aged rats.

2 October 2017

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Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective

2 October 2017

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Central obesity and increased risk of dementia more than three decades later

2 October 2017

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2 October 2017

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Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons

2 October 2017

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Pathologically activated therapeutics for neuroprotection

2 October 2017

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Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials

2 October 2017

1 reference

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Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

2 October 2017

1 reference

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Intracellular amyloid-beta in Alzheimer's disease

2 October 2017

1 reference

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Alterations in intrinsic neuronal excitability during normal aging.

2 October 2017

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2 October 2017

Memantine for dementia

1 reference

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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

2 October 2017

1 reference

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Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

2 October 2017

1 reference

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Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study

2 October 2017

1 reference

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PPARs: therapeutic targets for metabolic disease

2 October 2017

1 reference

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Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats

2 October 2017

1 reference

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Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults

2 October 2017

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Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

2 October 2017

1 reference

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11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory

2 October 2017

1 reference

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2 October 2017

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Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised

2 October 2017

1 reference

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Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

2 October 2017

1 reference

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Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

2 October 2017

1 reference

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Changes in Apolipoprotein E Expression in Response to Dietary and Pharmacological Modulation of Cholesterol

2 October 2017

1 reference

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The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence

2 October 2017

1 reference

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

2 October 2017

1 reference

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Therapeutic Potential of Peroxisome Proliferator-Activated Receptor Agonists for Neurological Disease

2 October 2017

1 reference

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TM4: a free, open-source system for microarray data management and analysis

2 October 2017

1 reference

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Nuclear receptors and the control of metabolism

2 October 2017

1 reference

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Cholesterol, A beta and Alzheimer's disease

2 October 2017

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The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

2 October 2017

1 reference

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Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease

2 October 2017

1 reference

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Remembrance of arguments past: how well is the glutamate receptor hypothesis of LTP holding up after 20 years?

2 October 2017

1 reference

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Differential effects of NMDA-receptor antagonists on long-term potentiation and hypoxic/hypoglycaemic excitotoxicity in hippocampal slices

2 October 2017

1 reference

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Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease

2 October 2017

1 reference

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11beta-hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive control

11 July 2018

1 reference

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Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathology.

11 July 2018

1 reference

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Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines

11 July 2018

1 reference

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Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology

11 July 2018

1 reference

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Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease

11 July 2018

1 reference

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Lipophilicity as a determinant of thiazolidinedione action in vitro: findings from BLX-1002, a novel compound without affinity to PPARs.

11 July 2018

1 reference

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Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease.

23 September 2018

1 reference

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Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice

23 September 2018

1 reference

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Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes

23 September 2018

1 reference

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Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease.

23 September 2018

1 reference

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Cognitive decline associated with dementia and type 2 diabetes: the interplay of risk factors.

23 September 2018

1 reference

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Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.

23 September 2018

1 reference

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Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Combination therapy of rosiglitazone, a peroxisome proliferator-activated receptor-gamma ligand, and NMDA receptor antagonist (MK-801) on experimental embolic stroke in rats

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Longitudinal study of the effects of a high-fat diet on glucose regulation, hippocampal function, and cerebral insulin sensitivity in C57BL/6 mice

23 September 2018

1 reference

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Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-susceptible EL mice.

23 September 2018

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Troglitazone, a peroxisome proliferator-activated receptor-gamma agonist, decreases tau phosphorylation in CHOtau4R cells.

23 September 2018

1 reference

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Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.

23 September 2018

1 reference

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Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Improving metabolic control leads to better working memory in adults with type 2 diabetes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Role of protein phosphatases in estrogen-mediated neuroprotection.

23 September 2018

1 reference

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Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivo

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

17beta-estradiol benzoate decreases the AHP amplitude in CA1 pyramidal neurons

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease?

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Spatial discrimination, reversal and active or passive avoidance learning in rats with KA-induced neuronal depletions in dorsal hippocampus.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378773

Correlation between Abetax-40-, Abetax-42-, and Abetax-43-containing amyloid plaques and cognitive decline

23 September 2018

1 reference

12 December 2020

17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced

1 reference

12 December 2020

Rosiglitazone cools down inflammation in the metabolic syndrome

1 reference

12 December 2020

Relation of improvement in endothelium-dependent flow-mediated vasodilation after rosiglitazone to changes in asymmetric dimethylarginine, endothelin-1, and C-reactive protein in nondiabetic patients with the metabolic syndrome

1 reference

12 December 2020

Deaths: preliminary data for 2009.

1 reference

12 December 2020

Identifiers

DOI

10.3233/JAD-2012-111661

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22495349

1 reference