Conserved non-genic sequences - an unexpected feature of mammalian genomes (Q36045183)

11 August 2017

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title

Conserved non-genic sequences - an unexpected feature of mammalian genomes (English)

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11 August 2017

Stilianos Antonarakis

series ordinal

3

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11 August 2017

2

Alexandre Reymond

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PubMed ID

15716910

11 August 2017

Emmanouil Dermitzakis

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1

object named as

Emmanouil T Dermitzakis

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11 August 2017

1 February 2005

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11 August 2017

Nature Reviews Genetics

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11 August 2017

6

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11 August 2017

151-157

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11 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrg1527

11 August 2017

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Conserved noncoding sequences are reliable guides to regulatory elements.

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Numerous potentially functional but non-genic conserved sequences on human chromosome 21

21 January 2018

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Initial sequencing and comparative analysis of the mouse genome

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Evolutionarily conserved sequences on human chromosome 21

21 January 2018

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Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome

21 January 2018

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Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

21 January 2018

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Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution

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Identification and characterization of multi-species conserved sequences

21 January 2018

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Evolutionarily conserved noncoding DNA in the human genome: how much and what for?

21 January 2018

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Comparative analyses of multi-species sequences from targeted genomic regions

21 January 2018

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GALA, a database for genomic sequence alignments and annotations

21 January 2018

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Comparison of human chromosome 21 conserved nongenic sequences (CNGs) with the mouse and dog genomes shows that their selective constraint is independent of their genic environment

21 January 2018

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Ultraconserved Elements in the Human Genome

21 January 2018

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Scanning Human Gene Deserts for Long-Range Enhancers

21 January 2018

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The dog genome: survey sequencing and comparative analysis.

21 January 2018

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Active conservation of noncoding sequences revealed by three-way species comparisons

21 January 2018

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Noncoding sequences conserved in a limited number of mammals in the SIM2 interval are frequently functional

21 January 2018

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Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs).

21 January 2018

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Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents

21 January 2018

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Distinguishing regulatory DNA from neutral sites

21 January 2018

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Evolution of transcription factor binding sites in Mammalian gene regulatory regions: conservation and turnover

21 January 2018

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A significant fraction of conserved noncoding DNA in human and mouse consists of predicted matrix attachment regions

21 January 2018

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Differences in the localization and morphology of chromosomes in the human nucleus.

21 January 2018

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Nuclear organization in differentiating oligodendrocytes.

21 January 2018

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Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates.

21 January 2018

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Transvection effects in Drosophila

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Does looping and clustering in the nucleus regulate gene expression?

21 January 2018

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Phylogenetic shadowing of primate sequences to find functional regions of the human genome

21 January 2018

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Megabase deletions of gene deserts result in viable mice

21 January 2018

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β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

21 January 2018

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A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

21 January 2018

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Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

21 January 2018

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A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig.

21 January 2018

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A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse.

21 January 2018

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Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma

21 January 2018

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A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects.

21 January 2018

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The TWIST gene, although not disrupted in Saethre-Chotzen patients with apparently balanced translocations of 7p21, is mutated in familial and sporadic cases

21 January 2018

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A global control region defines a chromosomal regulatory landscape containing the HoxD cluster

21 January 2018

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Quantification of DNaseI-sensitivity by real-time PCR: quantitative analysis of DNaseI-hypersensitivity of the mouse beta-globin LCR

21 January 2018

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Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

21 January 2018

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Genetic analysis of genome-wide variation in human gene expression

21 January 2018

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EVOLUTION: Heirlooms in the Attic

21 January 2018

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Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling

21 January 2018

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Strong conservation of non-coding sequences during vertebrates evolution: potential involvement in post-transcriptional regulation of gene expression

31 March 2020

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Long Human–Mouse Sequence Alignments Reveal Novel Regulatory Elements: A Reason to Sequence the Mouse Genome

31 March 2020

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Transcriptional enhancers can act in trans

31 March 2020

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Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites

31 March 2020

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Position effect in human genetic disease

31 March 2020

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Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9.

31 March 2020

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A duplication/paracentric inversion associated with familial X-linked deafness (DFN3) suggests the presence of a regulatory element more than 400 kb upstream of the POU3F4 gene.

31 March 2020

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Identification of a hot spot for microdeletions in patients with X- linked deafness type 3 (DFN3) 900 kb proximal to the DFN3 gene POU3F4

31 March 2020

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Construction and analysis of a sequence-ready map in 4q25: Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks approximately 90 kb upstream of this gene

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1527

1 reference

11 August 2017

1 reference

PubMed ID

15716910