Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: possible effect of age, liver disease and length of therapy (Q36053279)

11 August 2017

Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: possible effect of age, liver disease and length of therapy (English)

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11 August 2017

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M Kimura

1

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11 August 2017

I Ieiri

2

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11 August 2017

Y Wada

3

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11 August 2017

K Mamiya

4

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11 August 2017

A Urae

5

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11 August 2017

E Iimori

6

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11 August 2017

T Sakai

7

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11 August 2017

K Otsubo

8

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11 August 2017

S Higuchi

9

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11 August 2017

language of work or name

English

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publication date

1 January 1999

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British Journal of Clinical Pharmacology

11 August 2017

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11 August 2017

47

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11 August 2017

1

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11 August 2017

115-119

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Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

11 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Focus on omeprazole, lansoprazole and pantoprazole

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

Assessment of liver metabolic function. Clinical implications

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

Interphenotype differences in disposition and effect on gastrin levels of omeprazole—suitability of omeprazole as a probe for CYP2C19

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

Omeprazole drug interaction studies

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

Evidence for the effect of gender on activity of (S)-mephenytoin 4'-hydroxylase (CYP2C19) in a Chinese population.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014196

Pharmacokinetic study of omeprazole in elderly healthy volunteers

23 September 2018

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12 December 2020

Pharmacokinetics of [14C]omeprazole in patients with liver cirrhosis

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12 December 2020

Mephenytoin phenotyping: lack of haematologic effect and timing of urine collections

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12 December 2020

Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects

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12 December 2020

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study

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12 December 2020

Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, C gamma P2C19m1 in exon 5 and C gamma P2C19m2 in exon 4, in Japanese subjects

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12 December 2020

Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype

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12 December 2020

CYP2C19 genotype and phenotype determined by omeprazole in a Korean population

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12 December 2020

10.1046/J.1365-2125.1999.00858.X

Identifiers

DOI

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11 August 2017

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11 August 2017

PubMed publication ID

10073749

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