Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease (Q36061425)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22615377%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease (English)

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2 February 2020

1 reference

2

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2 February 2020

1

Patcharee Ritprajak

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2 February 2020

author name string

Yasuyo Sano

series ordinal

3

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2 February 2020

Kinya Otsu

series ordinal

4

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2 February 2020

Jin Mo Park

series ordinal

5

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2 February 2020

language of work or name

English

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publication date

21 May 2012

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Proceedings of the National Academy of Sciences of the United States of America

2 February 2020

published in

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2 February 2020

volume

109

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2 February 2020

issue

23

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2 February 2020

page(s)

9089-9094

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Neutrophils, from marrow to microbes

2 February 2020

cites work

1 reference

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Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells

2 October 2017

1 reference

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Skin immune sentinels in health and disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization

2 October 2017

1 reference

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Exploring the full spectrum of macrophage activation

2 October 2017

1 reference

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Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.

2 October 2017

1 reference

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MAPKAP kinases - MKs - two's company, three's a crowd

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384166

Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

27 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1202984109

Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1202984109

Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1202984109

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1202984109

Keratinocyte-associated B7-H1 directly regulates cutaneous effector CD8+ T cell responses

21 January 2018

1 reference

12 December 2020

A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis

1 reference

12 December 2020

Peptide immunization indicates that CD8+ T cells are the dominant effector cells in trinitrophenyl-specific contact hypersensitivity

1 reference

12 December 2020

Major histocompatibility complex class I-restricted CD8+ T cells and class II-restricted CD4+ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene

1 reference

12 December 2020

Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1202984109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22615377%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

0 references

1 reference

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2 February 2020

PubMed publication ID

22615377

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22615377%20AND%20SRC:MED&resulttype=core&format=json