Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design (Q36061570)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

main subject

Plasmodium falciparum

0 references

protein design

0 references

chaperone protein ClpB1

1 reference

GeneDB

11 September 2018

heat shock protein 101

1 reference

11 September 2018

0 references

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Pascal F. Egea

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

author name string

Andrew P AhYoung

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Duilio Cascio

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

language of work or name

1 reference

14 July 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

volume

24

1 reference

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18 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

page(s)

1508-1520

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

Organization, function and substrates of the essential Clp protease system in plastids

18 February 2020

cites work

1 reference

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Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex

2 October 2017

1 reference

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PTEX is an essential nexus for protein export in malaria parasites

2 October 2017

1 reference

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PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes

2 October 2017

1 reference

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Bacterial caseinolytic proteases as novel targets for antibacterial treatment

2 October 2017

1 reference

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Accurate SAXS profile computation and its assessment by contrast variation experiments

2 October 2017

1 reference

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The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth

2 October 2017

1 reference

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Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source

2 October 2017

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Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes

2 October 2017

1 reference

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Small-angle X-ray scattering on biological macromolecules and nanocomposites in solution

2 October 2017

1 reference

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Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum

2 October 2017

1 reference

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Uncovering common principles in protein export of malaria parasites

2 October 2017

1 reference

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Flexible connection of the N-terminal domain in ClpB modulates substrate binding and the aggregate reactivation efficiency

2 October 2017

1 reference

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Linking Crystallographic Model and Data Quality

2 October 2017

1 reference

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Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

2 October 2017

1 reference

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Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery

2 October 2017

1 reference

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Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)

2 October 2017

1 reference

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Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

ClpXP, an ATP-powered unfolding and protein-degradation machine

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Molecular Basis for the Unique Role of the AAA+ Chaperone ClpV in Type VI Protein Secretion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Structure and mechanism of the hexameric MecA-ClpC molecular machine

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Crystallization of small proteins assisted by green fluorescent protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Local and global mobility in the ClpA AAA+ chaperone detected by cryo-electron microscopy: functional connotations

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.

2 October 2017

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

2 October 2017

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2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

A newly discovered protein export machine in malaria parasites

2 October 2017

1 reference

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Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPases

2 October 2017

1 reference

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Phasercrystallographic software

2 October 2017

1 reference

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The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism

2 October 2017

1 reference

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Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion

2 October 2017

1 reference

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Hsp104 and ClpB: protein disaggregating machines

2 October 2017

1 reference

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Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

The malaria secretome: from algorithms to essential function in blood stage infection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

ClpP: a distinctive family of cylindrical energy-dependent serine proteases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Cytotoxin ClyA from Escherichia coli assembles to a 13-meric pore independent of its redox-state

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Adaptor protein controlled oligomerization activates the AAA+ protein ClpC

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Engineering and characterization of a superfolder green fluorescent protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

A host-targeting signal in virulence proteins reveals a secretome in malarial infection

2 October 2017

1 reference

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Targeting malaria virulence and remodeling proteins to the host erythrocyte

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Coot: model-building tools for molecular graphics

2 October 2017

1 reference

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Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Protein binding and disruption by Clp/Hsp100 chaperones

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Crystal structure of the heterodimeric complex of the adaptor, ClpS, with the N-domain of the AAA+ chaperone, ClpA

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Electrostatics of nanosystems: application to microtubules and the ribosome

2 October 2017

1 reference

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Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) disrupts cytoadherence of malaria-infected red blood cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

A novel role for 100 kD heat shock proteins in the parasite Leishmania donovani

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Improved R-factors for diffraction data analysis in macromolecular crystallography

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Protein disaggregation mediated by heat-shock protein Hsp104.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Characterization and cloning of the gene encoding the vacuolar membrane protein EXP-2 from Plasmodium falciparum

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Two putative protein export regulators promote Plasmodium blood stage development in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Biochemical characterization of the apicoplast-targeted AAA+ ATPase ClpB from Plasmodium falciparum

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Protein unfolding is an essential requirement for transport across the parasitophorous vacuolar membrane of Plasmodium falciparum

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

The heat-shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Role of the Clp system in stress tolerance, biofilm formation, and intracellular invasion in Porphyromonas gingivalis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

The effects of anti-bacterials on the malaria parasite Plasmodium falciparum.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

The N-terminal domain of Escherichia coli ClpB enhances chaperone function

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Crystallographic investigation of peptide binding sites in the N-domain of the ClpA chaperone

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

Crystal structure of the E. coli Hsp100 ClpB N-terminal domain

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570544

CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FPRO.2739

The N-terminal zinc binding domain of ClpX is a dimerization domain that modulates the chaperone function

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26130467

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/PRO.2739

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

26130467

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26130467%20AND%20SRC:MED&resulttype=core&format=json