The role of notch in modeling and maintaining the vasculature (Q36067007)

12 August 2017

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title

The role of notch in modeling and maintaining the vasculature (English)

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12 August 2017

Aly Karsan

1

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12 August 2017

1 January 2005

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Canadian Journal of Physiology and Pharmacology

12 August 2017

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12 August 2017

83

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12 August 2017

1

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12 August 2017

14-23

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The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation

12 August 2017

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An overview of the Notch signalling pathway

21 January 2018

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The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity

21 January 2018

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Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

21 January 2018

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Notch-induced proteolysis and nuclear localization of the Delta ligand

21 January 2018

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Notch pathway: making sense of suppressor of hairless

21 January 2018

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Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: implications in cell-cycle regulation.

21 January 2018

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Mechanisms of angiogenesis and arteriogenesis

21 January 2018

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Developmental biology. One cell, two fates.

21 January 2018

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Clinical spectrum of CADASIL: a study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

21 January 2018

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Regulation of endothelial cell survival and apoptosis during angiogenesis

21 January 2018

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Endothelial cell diversity revealed by global expression profiling

21 January 2018

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Molecular mechanisms of blood vessel growth

21 January 2018

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Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

21 January 2018

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Vasculogenesis and the search for the hemangioblast

21 January 2018

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Familial Tetralogy of Fallot caused by mutation in the jagged1 gene

21 January 2018

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The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

21 January 2018

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Structural conservation of Notch receptors and ligands

21 January 2018

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Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis.

21 January 2018

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Apoptosis in atherosclerosis: pathological and pharmacological implications.

21 January 2018

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Glycosylation regulates Notch signalling.

21 January 2018

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Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models

21 January 2018

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Arteriogenesis: the development and growth of collateral arteries

21 January 2018

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Endothelial proliferation in tumours and normal tissues: Continuous labelling studies

21 January 2018

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Lipopolysaccharide signals an endothelial apoptosis pathway through TNF receptor-associated factor 6-mediated activation of c-Jun NH2-terminal kinase

21 January 2018

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The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

21 January 2018

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Cell movements during gastrulation: snail dependent and independent pathways

21 January 2018

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HES and HERP families: multiple effectors of the Notch signaling pathway

21 January 2018

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Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.

21 January 2018

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Notch signalling pathway and human diseases

21 January 2018

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Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients

21 January 2018

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The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

21 January 2018

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Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis

21 January 2018

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Vascular anomalies in Alagille syndrome: a significant cause of morbidity and mortality

21 January 2018

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Tumor necrosis factor and endothelial cell death.

21 January 2018

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Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1

21 January 2018

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Identity and function of γ‐secretase

21 January 2018

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21 January 2018

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Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation

21 January 2018

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The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

21 January 2018

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sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation

21 January 2018

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Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation

21 January 2018

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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

21 January 2018

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Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction

21 January 2018

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Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis

21 January 2018

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The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome

21 January 2018

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Characterization of Notch receptor expression in the developing mammalian heart and liver.

21 January 2018

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The polarisation of the anteroposterior axis in Drosophila

21 January 2018

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Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data

21 January 2018

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Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways

21 January 2018

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Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa

21 January 2018

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Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

21 January 2018

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The snail superfamily of zinc-finger transcription factors

21 January 2018

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Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects

21 January 2018

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Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation

21 January 2018

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Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression

21 January 2018

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Mutations in the human Jagged1 gene are responsible for Alagille syndrome

21 January 2018

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Notch signalling in hematopoiesis

21 January 2018

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Notch inhibition of E47 supports the existence of a novel signaling pathway

21 January 2018

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Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1

21 January 2018

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The role of Notch in tumorigenesis: oncogene or tumour suppressor?

21 January 2018

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Notch regulation of lymphocyte development and function.

21 January 2018

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Activation of Notch signaling pathway precedes heart regeneration in zebrafish

21 January 2018

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Mechanisms of angiogenesis

21 January 2018

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Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

21 January 2018

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Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.

21 January 2018

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Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition.

21 January 2018

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Regulation of notch signaling activity

21 January 2018

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Functional diversity among Notch1, Notch2, and Notch3 receptors

21 January 2018

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The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

21 January 2018

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Jagged1 mutations in alagille syndrome

21 January 2018

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Enhanced gene activation by Notch and BMP signaling cross-talk

21 January 2018

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Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate

21 January 2018

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Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression

21 January 2018

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Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

21 January 2018

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Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium

21 January 2018

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Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

21 January 2018

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Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis

21 January 2018

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Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK

21 January 2018

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Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

21 January 2018

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Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor

21 January 2018

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Molecular cloning of delta-4, a new mouse and human Notch ligand

21 January 2018

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gridlock, an HLH gene required for assembly of the aorta in zebrafish

21 January 2018

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Gridlock signalling pathway fashions the first embryonic artery

21 January 2018

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An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/Y04-125

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12 August 2017

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PubMed ID

15759046