The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage (Q34173117)

31 July 2017

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. (English)

1 reference

31 July 2017

Takeshi Ikeuchi

1

1 reference

PubMed ID

12551931

31 July 2017

Sangram S Sisodia

series ordinal

2

1 reference

PubMed ID

12551931

31 July 2017

language of work or name

English

0 references

publication date

24 January 2003

1 reference

Journal of Biological Chemistry

31 July 2017

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31 July 2017

278

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31 July 2017

10

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31 July 2017

7751-7754

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Alzheimer's disease: genetic studies and transgenic models

31 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Nuclear access and action of notch in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Jagged: a mammalian ligand that activates Notch1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Processing of the notch ligand delta by the metalloprotease Kuzbanian

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Down-regulation of Delta by proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200711200

21 January 2018

Identifiers

DOI

10.1074/JBC.C200711200

1 reference

31 July 2017

1 reference

PubMed ID

12551931