Design of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's disease (Q36085361)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22294150%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Design of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's disease (English)

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21 January 2020

0 references

1 reference

1

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21 January 2020

Gürdal Şahin

series ordinal

2

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21 January 2020

Tomas Bjorklund

series ordinal

4

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21 January 2020

author name string

Deniz Kirik

series ordinal

3

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21 January 2020

publication date

31 January 2012

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21 January 2020

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21 January 2020

volume

20

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21 January 2020

page(s)

1315-1326

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21 January 2020

issue

7

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Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain.

21 January 2020

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

2 October 2017

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Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer

2 October 2017

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Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease

2 October 2017

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Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement.

2 October 2017

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Low selenium diet induces tyrosine hydroxylase enzyme in nigrostriatal system of the rat.

2 October 2017

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Levodopa motor complications in Parkinson's disease

2 October 2017

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Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease

2 October 2017

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Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach

2 October 2017

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Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease.

2 October 2017

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2 October 2017

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Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism

2 October 2017

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In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase

2 October 2017

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Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.

11 July 2018

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New antioxidant mixture for long term stability of serotonin, dopamine and their metabolites in automated microbore liquid chromatography with dual electrochemical detection.

11 July 2018

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Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats

23 September 2018

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Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

23 September 2018

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Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice.

23 September 2018

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23 September 2018

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Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats.

23 September 2018

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The Corridor Task: a simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the striatum.

23 September 2018

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23 September 2018

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Comparison of neurotoxicity following repeated administration of l-dopa, d-dopa and dopamine to embryonic mesencephalic dopamine neurons in cultures derived from Fisher 344 and Sprague-Dawley donors.

23 September 2018

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Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts

23 September 2018

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23 September 2018

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23 September 2018

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PubMed

12 December 2020

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12 December 2020

Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat

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PubMed

12 December 2020

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12 December 2020

Aromatic Amino Acids and Modification of Parkinsonism

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Crossref

https://api.crossref.org/works/10.1038%2FMT.2012.1

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/MT.2012.1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22294150%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22294150%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

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