The evolving field of biodefence: therapeutic developments and diagnostics (Q36085668)

12 August 2017

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title

The evolving field of biodefence: therapeutic developments and diagnostics (English)

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12 August 2017

4

Sina Bavari

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12 August 2017

3

Alan L Schmaljohn

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12 August 2017

James C Burnett

1

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12 August 2017

Erik A Henchal

series ordinal

2

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12 August 2017

publication date

1 April 2005

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Nature Reviews Drug Discovery

12 August 2017

published in

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12 August 2017

volume

4

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12 August 2017

issue

4

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12 August 2017

page(s)

281-297

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Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

12 August 2017

cites work

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Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages

21 January 2018

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Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

21 January 2018

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Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor

21 January 2018

1 reference

Identification of the cellular receptor for anthrax toxin

21 January 2018

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Crystal structure of a complex between anthrax toxin and its host cell receptor

21 January 2018

1 reference

Polyarginines are potent furin inhibitors

21 January 2018

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Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo

21 January 2018

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Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine

21 January 2018

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Dominant-Negative Mutants of a Toxin Subunit: An Approach to Therapy of Anthrax

21 January 2018

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A dominant negative mutant of Bacillus anthracis protective antigen inhibits anthrax toxin action in vivo

21 January 2018

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Designing a polyvalent inhibitor of anthrax toxin

21 January 2018

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Three-dimensional model of the pore form of anthrax protective antigen. Structure and biological implications.

21 January 2018

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Screening inhibitors of anthrax lethal factor

21 January 2018

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The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

21 January 2018

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A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor protease

21 January 2018

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Identification of small molecule inhibitors of anthrax lethal factor

21 January 2018

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Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor

21 January 2018

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Potent inhibitors of anthrax lethal factor from green tea

21 January 2018

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Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides

21 January 2018

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Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough

21 January 2018

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Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection

21 January 2018

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Therapy and prophylaxis of inhaled biological toxins

21 January 2018

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Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells

21 January 2018

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Botulinum Toxin as a Biological Weapon: Medical and Public Health Management

21 January 2018

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Botulinum and tetanus neurotoxins: structure, function and therapeutic utility

21 January 2018

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Efficacy of certain quinolines as pharmacological antagonists in botulinum neurotoxin poisoning

21 January 2018

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Structural features of aminoquinolines necessary for antagonist activity against botulinum neurotoxin

21 January 2018

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Discovery and design of novel inhibitors of botulinus neurotoxin A: targeted 'hinge' peptide libraries

21 January 2018

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A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity

21 January 2018

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Synthesis of substrates and inhibitors of botulinum neurotoxin type A metalloprotease

21 January 2018

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Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

21 January 2018

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Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity

21 January 2018

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Crystal structure of botulinum neurotoxin type A and implications for toxicity

21 January 2018

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Substrate recognition strategy for botulinum neurotoxin serotype A.

21 January 2018

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Antagonism of botulinum toxin type A-induced cleavage of SNAP-25 in rat cerebral synaptosome by toosendanin

21 January 2018

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Efficacy of a novel metalloprotease inhibitor on botulinum neurotoxin B activity

21 January 2018

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Fluorigenic substrates for the protease activities of botulinum neurotoxins, serotypes A, B, and F.

21 January 2018

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Mechanism of action of clostridial neurotoxins and rational inhibitor design

21 January 2018

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Development of Potent Inhibitors of Botulinum Neurotoxin Type B

21 January 2018

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X-ray analysis of substrate analogs in the ricin A-chain active site

21 January 2018

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Structure-based identification of a ricin inhibitor

21 January 2018

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Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition

21 January 2018

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Aptamers: an emerging class of therapeutics

21 January 2018

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In vitro selection of RNA molecules that inhibit the activity of ricin A-chain

21 January 2018

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Ricin A-chain inhibitors resembling the oxacarbenium ion transition state

21 January 2018

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Ricin A-chain: kinetics, mechanism, and RNA stem-loop inhibitors

21 January 2018

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Use of intravenous immunoglobulin in the treatment of staphylococcal and streptococcal toxic shock syndromes and related illnesses.

21 January 2018

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Protective effects of niacinamide in staphylococcal enterotoxin-B-induced toxicity

21 January 2018

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High affinity T cell receptors from yeast display libraries block T cell activation by superantigens.

21 January 2018

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Therapeutic approaches to superantigen‐based diseases: a review

21 January 2018

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Peptide antagonists of superantigen toxins

21 January 2018

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In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists

21 January 2018

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Antiviral drugs in current clinical use.

21 January 2018

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Folate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses

21 January 2018

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Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry

21 January 2018

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DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.

21 January 2018

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The highly specific carbohydrate-binding protein cyanovirin-N: structure, anti-HIV/Ebola activity and possibilities for therapy

21 January 2018

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Discovery of antivirals against smallpox

21 January 2018

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Functional importance of the coiled-coil of the Ebola virus glycoprotein

21 January 2018

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The central structural feature of the membrane fusion protein subunit from the Ebola virus glycoprotein is a long triple-stranded coiled coil

21 January 2018

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Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain

21 January 2018

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Molecular mechanisms of filovirus cellular trafficking.

21 January 2018

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Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening

21 January 2018

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Differentiation of filoviruses by electron microscopy

21 January 2018

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Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses

21 January 2018

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Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture

21 January 2018

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Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event

21 January 2018

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Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys

21 January 2018

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Vaccine research efforts for filoviruses

21 January 2018

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Antigenicity and vaccine potential of Marburg virus glycoprotein expressed by baculovirus recombinants

21 January 2018

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Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes

21 January 2018

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Epitopes involved in antibody-mediated protection from Ebola virus

21 January 2018

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Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates.

21 January 2018

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DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge

21 January 2018

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Protection from Ebola virus mediated by cytotoxic T lymphocytes specific for the viral nucleoprotein

21 January 2018

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Immunization for Ebola virus infection

21 January 2018

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DNA vaccination with vaccinia virus L1R and A33R genes protects mice against a lethal poxvirus challenge

21 January 2018

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Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

21 January 2018

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Neutralizing and protective antibodies directed against vaccinia virus envelope antigens

21 January 2018

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Protective monoclonal antibodies define maturational and pH-dependent antigenic changes in sindbis virus E1 glycoprotein

21 January 2018

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Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin

21 January 2018

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Dendritic cells: In the forefront of immunopathogenesis and vaccine development - A review

21 January 2018

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The Ebola virus VP35 protein functions as a type I IFN antagonist.

21 January 2018

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Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation

21 January 2018

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Poxviruses and immune evasion

21 January 2018

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Ebola virus-like particles protect from lethal Ebola virus infection

21 January 2018

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Mechanisms of enveloped RNA virus budding

21 January 2018

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Intrinsic immunity: a front-line defense against viral attack

21 January 2018

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The interferon antiviral response: from viral invasion to evasion

21 January 2018

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Anthrax as a biological weapon, 2002: updated recommendations for management

21 January 2018

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21 January 2018

Management of anthrax

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Development of novel vaccines against anthrax in man.

21 January 2018

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Bactericidal activities of antibiotics against intracellular Francisella tularensis

21 January 2018

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Tularemia as a biological weapon: medical and public health management

21 January 2018

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21 January 2018

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Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings

21 January 2018

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Characterization of individual polynucleotide molecules using a membrane channel

21 January 2018

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Shedding Light on Microbial Detection

21 January 2018

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Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery

21 January 2018

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Global analysis of host cell gene expression late during cytomegalovirus infection reveals extensive dysregulation of cell cycle gene expression and induction of Pseudomitosis independent of US28 function

21 January 2018

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Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils

21 January 2018

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The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model

21 January 2018

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Toxicogenomics and systems toxicology: aims and prospects

21 January 2018

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Taking the measure of countermeasures: leaders' views on the nation's capacity to develop biodefense countermeasures

21 January 2018

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Hemorrhagic fever viruses as biological weapons: medical and public health management

21 January 2018

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Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo

21 January 2018

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Multiple Ebola Virus Transmission Events and Rapid Decline of Central African Wildlife

21 January 2018

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Ebola virus: from discovery to vaccine

21 January 2018

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Towards a vaccine against Ebola virus

21 January 2018

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Smallpox as a Biological Weapon

21 January 2018

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Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses

21 January 2018

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Myocarditis: the unexpected return of smallpox vaccine adverse events

21 January 2018

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Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox

21 January 2018

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Opening a bacillus anthracis-containing envelope, Capitol Hill, Washington, D.C.: the public health response

21 January 2018

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Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin

21 January 2018

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21 January 2018

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Prevention and treatment of bacterial diseases caused by bacterial bioterrorism threat agents

21 January 2018

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mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia

21 January 2018

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Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity

21 January 2018

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Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed

21 January 2018

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Passive antibody administration (immediate immunity) as a specific defense against biological weapons

21 January 2018

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Deciphering antibody properties that lead to potent botulinum neurotoxin neutralization

21 January 2018

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Epitope mapping of neutralizing botulinum neurotoxin A antibodies by phage display

21 January 2018

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Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody

21 January 2018

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High-affinity, protective antibodies to the binding domain of botulinum neurotoxin type A.

21 January 2018

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Immunological characteristics associated with the protective efficacy of antibodies to ricin

21 January 2018

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A novel recombinant vaccine which protects mice against ricin intoxication.

21 January 2018

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Human antibodies to bacterial superantigens and their ability to inhibit T-cell activation and lethality

21 January 2018

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Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination

21 January 2018

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Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis

21 January 2018

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Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

21 January 2018

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Antitoxins: novel strategies to target agents of bioterrorism

31 March 2020

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Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I

31 March 2020

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Intimate details of the most poisonous poison

31 March 2020

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Proteolysis of synthetic peptides by type A botulinum neurotoxin

31 March 2020

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Endoproteinase activity of type A botulinum neurotoxin: substrate requirements and activation by serum albumin

31 March 2020

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Type A botulinum neurotoxin proteolytic activity: development of competitive inhibitors and implications for substrate specificity at the S1' binding subsite

31 March 2020

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A novel mechanism for Clostridium botulinum neurotoxin inhibition

31 March 2020

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Evaluation of phosphoramidon and three synthetic phosphonates for inhibition of botulinum neurotoxin B catalytic activity

31 March 2020

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Buforin I, a natural peptide, inhibits botulinum neurotoxin B activity in vitro

31 March 2020

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Thio-derived disulfides as potent inhibitors of botulinum neurotoxin type B: implications for zinc interaction

31 March 2020

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Small tripeptide surrogates with low nanomolar affinity as potent inhibitors of the botulinum neurotoxin B metallo-proteolytic activity

31 March 2020

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Microbial Superantigens as Virulence Factors and Ways to Counteract Their Actions

31 March 2020

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Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation

31 March 2020

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The asialoglycoprotein receptor is a potential liver-specific receptor for Marburg virus

31 March 2020

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Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. International Scientific and Technical Committee

31 March 2020

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The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase

31 March 2020

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High-speed mass transit for poxviruses on microtubules

31 March 2020

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In vitro antibiotic susceptibility of Francisella tularensis isolated from humans and animals

31 March 2020

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Tularemia epidemic in northwestern Spain: clinical description and therapeutic response

31 March 2020

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31 March 2020

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Serological studies of patients with cutaneous and oral-oropharyngeal anthrax from northern Thailand

31 March 2020

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Protonation dynamics of the alpha-toxin ion channel from spectral analysis of pH-dependent current fluctuations

31 March 2020

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Simultaneous multianalyte detection with a nanometer-scale pore

31 March 2020

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Genome-wide responses of a pathogenic bacterium to its host

31 March 2020

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Pathogenesis of filoviral haemorrhagic fevers

31 March 2020

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31 March 2020

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Comparison of noninvasive sampling sites for early detection of Bacillus anthracis spores from rhesus monkeys after aerosol exposure

31 March 2020

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Modeling potential responses to smallpox as a bioterrorist weapon

31 March 2020

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Ricin. Mechanisms of cytotoxicity.

31 March 2020

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Identification and characterization of a neutralizing monoclonal antibody against botulinum neurotoxin serotype F, following vaccination with active toxin

31 March 2020

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Protection against ricin intoxication in vivo by anti-idiotype vaccination

31 March 2020

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Monoclonal antibody prophylaxis against the in vivo toxicity of ricin in mice

31 March 2020

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Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo

31 March 2020

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Finding a new vaccine in the ricin protein fold

31 March 2020

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Aerosolized specific antibody protects mice from lung injury associated with aerosolized ricin exposure

31 March 2020

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Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

31 March 2020

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Immune response to filovirus infections

31 March 2020

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12 December 2020

A national laboratory network for bioterrorism: evolution from a prototype network of laboratories performing routine surveillance.

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12 December 2020

Crystallographic evidence for doxorubicin binding to the receptor-binding site in Clostridium botulinum neurotoxin B

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12 December 2020

Bioterrorism: a new frontier for drug discovery and development

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12 December 2020

Monoclonal antibody to type F Clostridium botulinum toxin

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12 December 2020

Differences between extracellular and intracellular forms of poxvirus and their implications

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12 December 2020

Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systems

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12 December 2020

The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA.

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12 December 2020

Lethal factor active-site mutations affect catalytic activity in vitro.

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12 December 2020

Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin.

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12 December 2020

Prophylactic and therapeutic efficacy of an avian antitoxin in ricin intoxication.

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12 December 2020

Smallpox vaccination and adverse reactions. Guidance for clinicians.

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12 December 2020

Epitope regions in the heavy chain of Clostridium botulinum type E neurotoxin recognized by monoclonal antibodies

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12 December 2020

Comparison of therapeutic effects of antibiotics of the tetracycline group in the treatment of anthrax caused by a strain inheriting tet-gene of plasmid pBC16

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12 December 2020

Passive immunization of Ebola virus-infected cynomolgus monkeys with immunoglobulin from hyperimmune horses

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12 December 2020

Antimicrobial susceptibility testing of Francisella tularensis with a modified Mueller-Hinton broth

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12 December 2020

Sensitivity to macrolide antibiotics and lincomycin in Francisella tularensis holarctica.

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12 December 2020

Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms

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12 December 2020

Susceptibility pattern of Scandinavian Francisella tularensis isolates with regard to oral and parenteral antimicrobial agents.

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12 December 2020

Current laboratory methods for biological threat agent identification

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12 December 2020

Oligonucleotide, antibody and peptide therapeutics--from design to the clinic.

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12 December 2020

Passive protection by polyclonal antibodies against Bacillus anthracis infection in guinea pigs

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12 December 2020

Learning from our foes: a novel vaccine concept for influenza virus

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12 December 2020

RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes

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12 December 2020

Isolation and identification of the "Marbury virus".

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12 December 2020

[Sensitivity spectrum of Francisella tularensis to antibiotics and synthetic antibacterial drugs].

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12 December 2020

Identifiers

DOI

10.1038/NRD1694

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Dimensions Publication ID

12 August 2017

1048843121

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