Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway (Q36089263)

12 August 2017

Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway (English)

1 reference

12 August 2017

Xiaoping Cui

1

1 reference

PMCID

2040436

12 August 2017

Katheryn Meek

series ordinal

2

1 reference

PMCID

2040436

12 August 2017

language of work or name

English

0 references

publication date

15 October 2007

1 reference

Proceedings of the National Academy of Sciences of the United States of America

12 August 2017

1 reference

12 August 2017

104

1 reference

12 August 2017

43

1 reference

12 August 2017

17046-17051

1 reference

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Genomic instability due to V(D)J recombination-associated transposition.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Biochemical evidence for Ku-independent backup pathways of NHEJ

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Double-strand break repair in Ku86- and XRCC4-deficient cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Nucleotide deletion and P addition in V(D)J recombination: a determinant role of the coding-end sequence

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Recent advances in understanding V(D)J recombination.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

2 October 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

2 October 2017

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

The V(D)J recombination activating gene, RAG-1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Impairment of V(D)J recombination in double-strand break repair mutants

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2040436

Antigen receptor gene rearrangement

27 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

Backup pathways of NHEJ are suppressed by DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

IgH class switching and translocations use a robust non-classical end-joining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

V(D)J recombination and RAG-mediated transposition in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

Rag mutations reveal robust alternative end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0610928104

Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17939999

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17939999

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0610928104

1 reference

12 August 2017

0 references

1 reference

12 August 2017

1 reference

PMCID

2040436