Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs (Q36096851)

12 August 2017

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title

Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs (English)

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12 August 2017

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Todd D Gould

1

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12 August 2017

Husseini K Manji

series ordinal

2

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12 August 2017

language of work or name

English

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publication date

1 July 2005

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12 August 2017

Neuropsychopharmacology

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12 August 2017

30

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12 August 2017

1223-1237

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12 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/sj.npp.1300731

12 August 2017

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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

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A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder

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A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression

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Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP.

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Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

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Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium

21 January 2018

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Endocrine factors in the etiology of postpartum depression

21 January 2018

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Signaling by insulin-like growth factor 1 in brain

21 January 2018

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Molecular clock genes in man and lower animals: possible implications for circadian abnormalities in depression

21 January 2018

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Norepinephrine in depressive reactions. A review

21 January 2018

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Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus

21 January 2018

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Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

21 January 2018

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The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.

21 January 2018

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Neuroprotective effects of lithium in cultured cells and animal models of diseases.

21 January 2018

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GSK3 inhibitors: development and therapeutic potential

21 January 2018

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Cancer morbidity in psychiatric patients: influence of lithium carbonate treatment.

21 January 2018

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Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

21 January 2018

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Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

21 January 2018

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Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium

21 January 2018

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Neuroimaging studies of mood disorders

21 January 2018

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Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment

21 January 2018

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Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

21 January 2018

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Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

21 January 2018

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Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle

21 January 2018

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

21 January 2018

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Suicide risk in bipolar disorder during treatment with lithium and divalproex

21 January 2018

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The endophenotype concept in psychiatry: etymology and strategic intentions

21 January 2018

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In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3.

21 January 2018

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AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium treatment enhances estradiol-induced proliferation and hyperplasia formation in the uterus of mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium and valproic acid: parallels and contrasts in diverse signaling contexts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

The circadian system and the therapeutics of the affective disorders

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Effects of lithium carbonate on methylphenidate-induced mood, behavior, and cognitive processes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Mood stabilizers, glycogen synthase kinase-3beta and cell survival

21 January 2018

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The glamour and gloom of glycogen synthase kinase-3

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

21 January 2018

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Activation of protein kinase B (Akt) signaling after electroconvulsive shock in the rat hippocampus.

21 January 2018

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The effects of clozapine on the GSK-3-mediated signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium-mediated phosphorylation of glycogen synthase kinase-3beta involves PI3 kinase-dependent activation of protein kinase C-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

A molecular mechanism for the effect of lithium on development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Rhythms and the pharmacology of lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Wnt/beta-catenin and estrogen signaling converge in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Antidepressant-like properties of zinc in rodent forced swim test

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Effects of trimebutine maleate on delayed rectifier K+ currents in guinea-pig ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Endophenotypes in bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

The Wnt signaling pathway in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

The cellular neurobiology of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Neuroplasticity and cellular resilience in mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Glycogen synthase kinase 3beta as a likely target for the action of lithium on circadian clocks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

The role of estrogen in mood disorders in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Depression: a new animal model sensitive to antidepressant treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Cell pathology in bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Comparing clockworks: mouse versus fly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Biphasic changes in the Ser-9 phosphorylation of glycogen synthase kinase-3beta after electroconvulsive shock in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium inhibits glycogen synthase kinase-3 by competition for magnesium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

The catecholamine hypothesis of affective disorders: a review of supporting evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

21 January 2018

Lithium treatment at 52.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium treatment and prophylaxis in unipolar depression: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Diverse psychotomimetics act through a common signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Stimulatory effect of paeoniflorin on the release of noradrenaline from ileal synaptosomes of guinea-pig in-vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Lithium attenuates the activation-euphoria but not the psychosis induced by d-amphetamine in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Placebo response in studies of major depression: variable, substantial, and growing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Circadian rhythm mechanisms in affective illness and in antidepressant drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

A common mechanism of action for three mood-stabilizing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3α and β isoforms in patients with NIDDM

21 January 2018

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Mood disorders and medical illness: a major public health problem

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Lithium carbonate augmentation of antidepressant treatment. An effective prescription for treatment-refractory depression

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7 January 2021

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Effect of the New Antiepileptic Drug Levetiracetam in an Animal Model of Mania

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Lithium-induced increase in human brain grey matter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Electroconvulsive therapy of acute manic episodes: a review of 50 years' experience

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Arguments for the specificity of the antisuicidal effect of lithium.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Effect of berberine on proliferation, cell cycle and apoptosis in HeLa and L1210 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Acute lithium effects on rat brain glucose metabolism - in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Estradiol, in the CNS, targets several physiologically relevant membrane-associated proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300731

7 January 2021

Identifiers

DOI

10.1038/SJ.NPP.1300731

1 reference

Dimensions Publication ID

12 August 2017

0 references

1 reference