GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides (Q28205921)

positive regulation of amyloid-beta formation

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Christopher J Phiel

1

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Christina A Wilson

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Virginia M-Y Lee

3

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Peter S Klein

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

4

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language of work or name

English

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publication date

22 May 2003

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published in

Nature

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volume

423

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issue

6938

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page(s)

435-9

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cites work

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

22 April 2017

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

22 April 2017

1 reference

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

22 April 2017

1 reference

A molecular mechanism for the effect of lithium on development

22 April 2017

1 reference

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

22 April 2017

1 reference

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

22 April 2017

1 reference

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

22 April 2017

1 reference

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

22 April 2017

1 reference

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

22 April 2017

1 reference

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

22 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

22 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Molecular targets of lithium action

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

The specificities of protein kinase inhibitors: an update

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Presenilins are not required for A beta 42 production in the early secretory pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01640

7 January 2021

Identifiers

DOI

10.1038/NATURE01640

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

2680420

1008545424

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2680420

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference