NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα. (Q36098755)

12 August 2017

NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα. (English)

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12 August 2017

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Bärbel Schröfelbauer

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12 August 2017

Smarajit Polley

2

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12 August 2017

Marcelo Behar

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12 August 2017

Gourisankar Ghosh

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12 August 2017

Alexander Hoffmann

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12 August 2017

24 May 2012

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47

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111-121

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describes a project that uses

12 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3398199/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

1 reference

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Crystal structure of inhibitor of κB kinase β

2 October 2017

1 reference

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ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

2 October 2017

1 reference

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IKK Regulation and Human Genetics

2 October 2017

1 reference

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Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

The IKK complex, a central regulator of NF-kappaB activation

2 October 2017

1 reference

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The IKK complex contributes to the induction of autophagy

2 October 2017

1 reference

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The role of scaffold proteins in JNK signalling

2 October 2017

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GSK3: a multifaceted kinase in Wnt signaling

2 October 2017

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NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

2 October 2017

1 reference

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The NF-kappaB-independent functions of IKK subunits in immunity and cancer

2 October 2017

1 reference

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Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.

2 October 2017

1 reference

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Shared principles in NF-kappaB signaling

2 October 2017

1 reference

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IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

2 October 2017

1 reference

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Mechanisms of specificity in protein phosphorylation

2 October 2017

1 reference

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Substrate competition as a source of ultrasensitivity in the inactivation of Wee1.

2 October 2017

1 reference

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A fourth IkappaB protein within the NF-kappaB signaling module

2 October 2017

1 reference

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IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

2 October 2017

1 reference

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Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.

2 October 2017

1 reference

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Circuitry of nuclear factor kappaB signaling

2 October 2017

1 reference

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Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses

2 October 2017

1 reference

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Stimulus specificity of gene expression programs determined by temporal control of IKK activity

2 October 2017

1 reference

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Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae.

2 October 2017

1 reference

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The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop

2 October 2017

1 reference

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Reprogramming control of an allosteric signaling switch through modular recombination

2 October 2017

1 reference

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Differential phosphorylation of the signal-responsive domain of I kappa B alpha and I kappa B beta by I kappa B kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

MAP kinase cascades: scaffolding signal specificity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

What do scaffold proteins really do?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

Regulation of beta-catenin function by the IkappaB kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

Signal transduction: hanging on a scaffold.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

IKK-dependent, NF-κB-independent control of autophagic gene expression.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398199

10.1016/J.MOLCEL.2012.04.020

5 December 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22633953

1 reference