The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. (Q36109992)

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28 February 2020

title

The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression (English)

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28 February 2020

4

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28 February 2020

Zoltán Jakus

6

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28 February 2020

author name string

Zinan Zhou

1

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28 February 2020

David R Rawnsley

2

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28 February 2020

Lauren M Goddard

3

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28 February 2020

Xing-Jun Cao

5

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28 February 2020

Hui Zheng

7

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28 February 2020

Jisheng Yang

8

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28 February 2020

J Simon C Arthur

9

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28 February 2020

Kevin J Whitehead

10

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28 February 2020

Dean Li

11

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28 February 2020

Bin Zhou

12

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28 February 2020

Benjamin A Garcia

13

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28 February 2020

Mark L Kahn

15

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28 February 2020

Xiangjian Zheng

14

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28 February 2020

language of work or name

English

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publication date

1 January 2015

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28 February 2020

number of pages

13

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inferred from page(s)

published in

Developmental Cell

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28 February 2020

volume

32

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issue

2

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28 February 2020

page(s)

168-180

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Lack of CCM1 induces hypersprouting and impairs response to flow

28 February 2020

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Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease

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Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice

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A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.

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CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

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Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

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Recent insights into cerebral cavernous malformations: the molecular genetics of CCM.

2 October 2017

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Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype

2 October 2017

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Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells

2 October 2017

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The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

2 October 2017

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Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

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Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

2 July 2018

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Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase

2 July 2018

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EndMT contributes to the onset and progression of cerebral cavernous malformations

2 July 2018

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Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

23 September 2018

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Proteomic identification of the cerebral cavernous malformation signaling complex

23 September 2018

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Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations.

23 September 2018

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Klf2 is an essential regulator of vascular hemodynamic forces in vivo.

23 September 2018

1 reference

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santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish

23 September 2018

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Statins exert endothelial atheroprotective effects via the KLF2 transcription factor

23 September 2018

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Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

23 September 2018

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Zebrafish intestinal fatty acid binding protein (I-FABP) gene promoter drives gut-specific expression in stable transgenic fish.

23 September 2018

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heart of glass regulates the concentric growth of the heart in zebrafish.

23 September 2018

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Changes in Shear Stress–Related Gene Expression After Experimentally Altered Venous Return in the Chicken Embryo

23 September 2018

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An experimental study of the relation of cardiac jelly to the shape of the early chick embryonic heart

5 December 2018

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12 December 2020

Isolated noncompaction of the myocardium

1 reference

12 December 2020

Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region

1 reference

12 December 2020

KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium

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12 December 2020

10.1016/J.DEVCEL.2014.12.009

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625206%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625206%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

25625206

1 reference