Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex (Q36115080)

12 August 2017

Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex (English)

1 reference

12 August 2017

0 references

Tina Bilousova

3

0 references

Wayne W Poon

object named as

Wayne W Poon

series ordinal

6

0 references

Harry V Vinters

series ordinal

7

object named as

Harry V Vinters

1 reference

12 August 2017

5

Carol A Miller

1 reference

12 August 2017

10

Gregory M Cole

1 reference

12 August 2017

11

Karen Hoppens Gylys

1 reference

12 August 2017

8

Lindsey B Cornwell

1 reference

12 August 2017

4

Edmond Teng

1 reference

12 August 2017

9

Tommy Saing

1 reference

12 August 2017

Stephen Arold

1

1 reference

PMCID

3404604

12 August 2017

Patrick Sullivan

series ordinal

2

1 reference

12 August 2017

22 October 2011

1 reference

12 August 2017

Acta Neuropathologica

1 reference

12 August 2017

123

1 reference

12 August 2017

1

1 reference

12 August 2017

39-52

1 reference

https://scigraph.springernature.com/pub.10.1007/s00401-011-0892-1

12 August 2017

0 references

cites work

AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly

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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

2 October 2017

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2 October 2017

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Decreased clearance of CNS beta-amyloid in Alzheimer's disease

2 October 2017

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Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.

2 October 2017

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APOE and cholesterol homeostasis in Alzheimer's disease

2 October 2017

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ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice

2 October 2017

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Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

2 October 2017

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The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice.

2 October 2017

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Accumulation of intraneuronal Abeta correlates with ApoE4 genotype

2 October 2017

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The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration

2 October 2017

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ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

2 October 2017

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The neuropathology of probable Alzheimer disease and mild cognitive impairment

2 October 2017

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The role of apolipoprotein E in Alzheimer's disease

2 October 2017

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Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

2 October 2017

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

2 October 2017

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Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests.

2 October 2017

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ApoE promotes the proteolytic degradation of Abeta

2 October 2017

1 reference

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Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes

2 October 2017

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Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

2 October 2017

1 reference

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Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes

2 October 2017

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2 October 2017

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Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

2 October 2017

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

2 October 2017

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Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence

2 October 2017

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ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function

2 October 2017

1 reference

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

2 October 2017

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Control of synapse number by glia

2 October 2017

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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

2 October 2017

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Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2

2 October 2017

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Association of human, rat, and rabbit apolipoprotein E with beta-amyloid

2 October 2017

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Distribution of apolipoprotein E in senile plaques in brains with Alzheimer's disease: investigation with the confocal laser scan microscope

2 October 2017

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Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma

2 October 2017

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

2 October 2017

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Isoform-specific binding of apolipoprotein E to beta-amyloid

2 October 2017

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Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro

2 October 2017

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

2 October 2017

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Genetics of the apolipoprotein E system in man

2 October 2017

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Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Flow cytometric analysis of rat striatal nerve terminals

2 July 2018

1 reference

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A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging.

2 July 2018

1 reference

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Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Reduced levels of human apoE4 protein in an animal model of cognitive impairment

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

23 September 2018

1 reference

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Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

A rapid Percoll gradient procedure for preparation of synaptosomes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Effect of domain interaction on apolipoprotein E levels in mouse brain.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Premorbid effects of APOE on synaptic proteins in human temporal neocortex.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404604

Apolipoprotein E ε4 Is a Determinant for Alzheimer-Type Pathologic Features in Tauopathies, Synucleinopathies, and Frontotemporal Degeneration

21 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00401-011-0892-1

Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00401-011-0892-1

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00401-011-0892-1

Filipin as a flow microfluorometry probe for cellular cholesterol

21 January 2018

1 reference

12 December 2020

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI

1 reference

12 December 2020

Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

1 reference

12 December 2020

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

1 reference

12 December 2020

Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition

1 reference

12 December 2020

10.1007/S00401-011-0892-1

Identifiers

DOI

1 reference

12 August 2017

1 reference

12 August 2017

1 reference

PMCID

3404604