An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers (Q36123927)

12 August 2017

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers (English)

1 reference

12 August 2017

11

Gad Getz

0 references

Natalie Saini

Natalie Saini

5

0 references

Kin Chan

Kin Chan

1

0 references

Dmitry A. Gordenin

Dmitry A Gordenin

12

0 references

Piotr A Mieczkowski

Piotr A Mieczkowski

10

0 references

author name string

Steven A Roberts

2

1 reference

12 August 2017

Leszek J Klimczak

3

1 reference

12 August 2017

Joan F Sterling

4

1 reference

12 August 2017

Ewa P Malc

6

1 reference

12 August 2017

Jaegil Kim

7

1 reference

12 August 2017

David J Kwiatkowski

8

1 reference

12 August 2017

David C Fargo

9

1 reference

12 August 2017

language of work or name

English

0 references

publication date

10 August 2015

1 reference

12 August 2017

1 reference

12 August 2017

47

1 reference

12 August 2017

9

1 reference

12 August 2017

1067-1072

1 reference

https://scigraph.springernature.com/pub.10.1038/ng.3378

12 August 2017

0 references

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Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer

2 October 2017

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APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation

2 October 2017

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Molecular and genetic properties of tumors associated with local immune cytolytic activity

2 October 2017

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Hypermutation in human cancer genomes: footprints and mechanisms

2 October 2017

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APOBEC3B: pathological consequences of an innate immune DNA mutator

2 October 2017

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Diagnosis and management of urothelial carcinoma in situ of the lower urinary tract: a systematic review.

2 October 2017

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MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

2 October 2017

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Genetic basis for clinical response to CTLA-4 blockade in melanoma

2 October 2017

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FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

2 October 2017

1 reference

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Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

2 October 2017

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A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3'UTR enhances chromosomal DNA damage

2 October 2017

1 reference

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The somatic genomic landscape of chromophobe renal cell carcinoma

2 October 2017

1 reference

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Mutation signatures of carcinogen exposure: genome-wide detection and new opportunities for cancer prevention

2 October 2017

1 reference

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Break-induced replication is a source of mutation clusters underlying kataegis

2 October 2017

1 reference

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APOBEC3B gene overexpression in non-small-cell lung cancer

2 October 2017

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Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

2 October 2017

1 reference

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Comprehensive molecular characterization of urothelial bladder carcinoma

2 October 2017

1 reference

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Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

2 October 2017

1 reference

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APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

2 October 2017

1 reference

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The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis

2 October 2017

1 reference

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Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death

2 October 2017

1 reference

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Signatures of mutational processes in human cancer

2 October 2017

1 reference

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Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines

2 October 2017

1 reference

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An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

Evidence for APOBEC3B mutagenesis in multiple human cancers

2 October 2017

1 reference

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Mutational heterogeneity in cancer and the search for new cancer-associated genes

2 October 2017

1 reference

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APOBEC3 deletion polymorphism is associated with breast cancer risk among women of European ancestry

2 October 2017

1 reference

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DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

2 October 2017

1 reference

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A common deletion in the APOBEC3 genes and breast cancer risk

2 October 2017

1 reference

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APOBEC3B is an enzymatic source of mutation in breast cancer.

2 October 2017

1 reference

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Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent

2 October 2017

1 reference

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Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

2 October 2017

1 reference

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Mutational processes molding the genomes of 21 breast cancers

2 October 2017

1 reference

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Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

2 October 2017

1 reference

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APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

2 October 2017

1 reference

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Exploring the genomes of cancer cells: progress and promise

2 October 2017

1 reference

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DNA end resection--unraveling the tail

2 October 2017

1 reference

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Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

Mutator alleles of yeast DNA polymerase zeta.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

The delitto perfetto approach to in vivo site-directed mutagenesis and chromosome rearrangements with synthetic oligonucleotides in yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

Cytidine deamination of retroviral DNA by diverse APOBEC proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

Significance of root-mean-square deviation in comparing three-dimensional structures of globular proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

Orthologous mammalian APOBEC3A cytidine deaminases hypermutate nuclear DNA.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

pLogo: a probabilistic approach to visualizing sequence motifs.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

Low fidelity DNA synthesis by human DNA polymerase-eta.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594173

ON A METHOD OF ESTIMATING FREQUENCIES

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26258849

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG.3378

1 reference

12 August 2017

1 reference

12 August 2017

1 reference