Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis (Q39820482)

14 September 2017

title

Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis (English)

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14 September 2017

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6

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14 September 2017

Y Li

1

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14 September 2017

X Ye

2

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14 September 2017

C Tan

3

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14 September 2017

J-A Hongo

4

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14 September 2017

J Zha

5

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14 September 2017

D Kallop

7

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14 September 2017

M J C Ludlam

8

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14 September 2017

L Pei

9

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14 September 2017

language of work or name

English

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publication date

27 July 2009

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14 September 2017

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14 September 2017

volume

28

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14 September 2017

issue

39

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14 September 2017

page(s)

3442-3455

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https://scigraph.springernature.com/pub.10.1038/onc.2009.212

14 September 2017

exact match

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cites work

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

RETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

RETRACTED: A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Phosphatidylinositol 3-OH kinase-Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell line

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

New signals from the invasive front

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Expression of the proto-oncogene Axl in renal cell carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Receptor tyrosine kinases expressed in metastatic colon cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Axl receptor activation mediates laminar shear stress anti-apoptotic effects in human endothelial cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

The role of gamma-carboxylation in the anti-apoptotic function of gas6

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Multiple roles for the receptor tyrosine kinase axl in tumor formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Expression of the Axl receptor tyrosine kinase in human thyroid carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Axl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertension

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Functional and structural diversity of the human Dickkopf gene family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Immunobiology of the TAM receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

The Gas6/Axl system: a novel regulator of vascular cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Dickkopf genes are co-ordinately expressed in mesodermal lineages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Functional significance of Tie2 signaling in the adult vasculature

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

TAM receptor function in the retinal pigment epithelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

TAM receptors are pleiotropic inhibitors of the innate immune response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Structural basis for Gas6-Axl signalling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Twist mediates suppression of inflammation by type I IFNs and Axl

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Expression of axl in lung adenocarcinoma and correlation with tumor progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Coexpression of Gas6/Axl in human ovarian cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Increased vascularization in mice overexpressing angiopoietin-1

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.212

Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

Vascular-specific growth factors and blood vessel formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

AXL is a potential target for therapeutic intervention in breast cancer progression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.212

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.212

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14 September 2017

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