Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells (Q36136572)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22490436%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells (English)

1 reference

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28 January 2020

1 reference

1

1 reference

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28 January 2020

Yoshinobu Odaka

4

1 reference

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28 January 2020

Shile Huang

10

1 reference

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28 January 2020

2

Lei Liu

1 reference

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28 January 2020

author name string

Yan Luo

3

1 reference

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28 January 2020

Sanket Awate

5

1 reference

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28 January 2020

Hongyu Zhou

6

1 reference

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28 January 2020

Tao Shen

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22490436%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Shizhong Zheng

8

1 reference

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28 January 2020

Yin Lu

9

1 reference

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28 January 2020

publication date

3 April 2012

1 reference

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Cancer Prevention Research

28 January 2020

published in

1 reference

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28 January 2020

volume

5

1 reference

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28 January 2020

issue

5

1 reference

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28 January 2020

page(s)

778-787

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22490436%20AND%20SRC:MED&resulttype=core&format=json

Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice

28 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410745

Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation

2 October 2017

1 reference

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Cryptotanshinone suppressed inflammatory cytokines secretion in RAW264.7 macrophages through inhibition of the NF-κB and MAPK signaling pathways

2 October 2017

1 reference

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Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway

2 October 2017

1 reference

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The antitumor activity of the fungicide ciclopirox

2 October 2017

1 reference

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Mitochondrial control of caspase-dependent and -independent cell death

2 October 2017

1 reference

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Pathological roles of MAPK signaling pathways in human diseases

2 October 2017

1 reference

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Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway

2 October 2017

1 reference

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Plant polyphenols and tumors: from mechanisms to therapies, prevention, and protection against toxicity of anti-cancer treatments

2 October 2017

1 reference

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Signal integration by JNK and p38 MAPK pathways in cancer development

2 October 2017

1 reference

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Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway

2 October 2017

1 reference

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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells

2 October 2017

1 reference

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Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway

2 October 2017

1 reference

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trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways

2 October 2017

1 reference

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Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells.

2 October 2017

1 reference

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Antioxidant effects of green tea and its polyphenols on bladder cells

2 October 2017

1 reference

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Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins

2 October 2017

1 reference

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mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A.

2 October 2017

1 reference

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MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410745

Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410745

Cardiovascular effects of Danshen

2 October 2017

1 reference

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Regulation of MAPKs by growth factors and receptor tyrosine kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410745

Reactive oxygen species-induced activation of the MAP kinase signaling pathways

2 October 2017

1 reference

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Herbs or natural substances as complementary therapies for chronic kidney disease: ideas for future studies

2 October 2017

1 reference

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Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells

2 October 2017

1 reference

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Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use

2 October 2017

1 reference

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Curcumin inhibits ROS formation and apoptosis in methylglyoxal-treated human hepatoma G2 cells

2 October 2017

1 reference

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(-)Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis

2 October 2017

1 reference

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Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity

2 October 2017

1 reference

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Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

2 October 2017

1 reference

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Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells

2 October 2017

1 reference

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Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

2 October 2017

1 reference

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Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells

2 October 2017

1 reference

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Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection.

2 October 2017

1 reference

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Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress

2 October 2017

1 reference

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A salvianolic acid B-rich fraction of Salvia miltiorrhiza induces neointimal cell apoptosis in rabbit angioplasty model

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410745

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410745

Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death

2 October 2017

1 reference

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Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG(2) cells

2 October 2017

1 reference

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Molecular characterization of mitochondrial apoptosis-inducing factor

2 October 2017

1 reference

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Transformation of mammalian cells by constitutively active MAP kinase kinase

2 October 2017

1 reference

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Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-alpha-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410745

Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II.

23 September 2018

1 reference

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PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410745

Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier

23 September 2018

1 reference

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p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway

23 September 2018

1 reference

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Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

23 September 2018

1 reference

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Treatment of chronic liver diseases with traditional Chinese medicine.

23 September 2018

1 reference

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Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22490436

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22490436

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1940-6207.CAPR-11-0551

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22490436%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22490436%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

22490436

1 reference