The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism. (Q36137423)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22685292%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism (English)

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4 February 2020

1

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4 February 2020

Laura J. Vella

2

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4 February 2020

Roberto Cappai

5

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4 February 2020

author name string

Chi L L Pham

3

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4 February 2020

Kevin J Barnham

4

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4 February 2020

language of work or name

English

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publication date

8 June 2012

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Journal of Biological Chemistry

4 February 2020

published in

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4 February 2020

volume

287

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4 February 2020

issue

32

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4 February 2020

page(s)

26840-26853

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Copper promotes the trafficking of the amyloid precursor protein

4 February 2020

cites work

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2 October 2017

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2 October 2017

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Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

2 October 2017

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

2 October 2017

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2 October 2017

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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

2 October 2017

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Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains

2 October 2017

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Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set

2 October 2017

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

2 October 2017

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

2 October 2017

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2 October 2017

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2 October 2017

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Nature of the charged-group effect on the stability of the C-peptide helix

2 October 2017

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In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease

2 October 2017

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Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design

2 October 2017

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Expression of neuronal mRNAs in Alzheimer type degeneration of the nervous system

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 July 2018

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2 July 2018

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2 July 2018

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The role of glycosylation in synthesis and secretion of beta-amyloid precursor protein by Chinese hamster ovary cells.

2 July 2018

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beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

2 July 2018

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The beta A4 amyloid precursor protein binding to copper.

2 July 2018

1 reference

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Analysis of protein circular dichroism spectra for secondary structure using a simple matrix multiplication

2 July 2018

1 reference

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

2 July 2018

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Increasing amyloid peptide precursor production and its impact on Alzheimer's disease

2 July 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

2 July 2018

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The trans-Golgi network can be dissected structurally and functionally from the cisternae of the Golgi complex by brefeldin A

2 July 2018

1 reference

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Production of the Alzheimer amyloid beta protein by normal proteolytic processing

2 July 2018

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An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence

2 July 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

2 July 2018

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Metal ions modulate the folding and stability of the tumor suppressor protein S100A2.

2 July 2018

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Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms

23 September 2018

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Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

23 September 2018

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Copper perturbation in 2 monozygotic twins discordant for degree of cognitive impairment.

23 September 2018

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Amyloid precursor protein mRNA levels in Alzheimer's disease brain

23 September 2018

1 reference

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Elevation of serum copper levels in Alzheimer's disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411021

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

23 September 2018

1 reference

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The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

23 September 2018

1 reference

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Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

23 September 2018

1 reference

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Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

23 September 2018

1 reference

12 December 2020

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

1 reference

12 December 2020

Variable selection method improves the prediction of protein secondary structure from circular dichroism spectra

1 reference

12 December 2020

Analysis of peptides for helical prediction

1 reference

12 December 2020

Side chain contributions to the stability of alpha-helical structure in peptides

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M112.355743

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22685292%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22685292%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

PubMed publication ID

22685292

1 reference