Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. (Q36143247)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26219304%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia (English)

1 reference

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20 February 2020

1 reference

1

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20 February 2020

Gavin P. Robertson

15

1 reference

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20 February 2020

Sinisa Dovat

19

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20 February 2020

author name string

Chandrika Gowda

2

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20 February 2020

Xiaokang Pan

3

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20 February 2020

Yali Ding

4

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20 February 2020

Yongqing Tong

5

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20 February 2020

Bi-Hua Tan

6

1 reference

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20 February 2020

Haijun Wang

7

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20 February 2020

Sunil Muthusami

8

1 reference

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20 February 2020

Zheng Ge

9

1 reference

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20 February 2020

Mansi Sachdev

10

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20 February 2020

Shantu G Amin

11

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20 February 2020

Dhimant Desai

12

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20 February 2020

Krishne Gowda

13

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20 February 2020

Raghavendra Gowda

14

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20 February 2020

Hilde Schjerven

16

1 reference

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20 February 2020

Markus Muschen

17

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20 February 2020

Kimberly J Payne

18

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20 February 2020

language of work or name

English

0 references

publication date

28 July 2015

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20 February 2020

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20 February 2020

volume

126

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20 February 2020

issue

15

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20 February 2020

page(s)

1813-1822

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20 February 2020

1 reference

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Kinases, tails and more: regulation of PTEN function by phosphorylation

2 October 2017

1 reference

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Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600018

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

2 October 2017

1 reference

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Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor.

2 October 2017

1 reference

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Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells: biochemical evidence and therapeutic perspectives

2 October 2017

1 reference

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Transcriptional regulation of the Ikzf1 locus

2 October 2017

1 reference

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Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.

2 October 2017

1 reference

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CK2 kinase activity but not its binding to CK2 promoter regions is implicated in the regulation of CK2α and CK2β gene expressions

2 October 2017

1 reference

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Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling

2 October 2017

1 reference

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

2 October 2017

1 reference

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Cell cycle-specific function of Ikaros in human leukemia

2 October 2017

1 reference

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Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis

2 October 2017

1 reference

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Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene

2 October 2017

1 reference

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A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway

2 October 2017

1 reference

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CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy

2 October 2017

1 reference

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The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival

2 October 2017

1 reference

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Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.

2 October 2017

1 reference

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IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.

2 October 2017

1 reference

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Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors

2 October 2017

1 reference

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Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.

2 October 2017

1 reference

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Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy

2 October 2017

1 reference

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Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia

2 October 2017

1 reference

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IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report

2 October 2017

1 reference

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IL-7 Dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow

2 October 2017

1 reference

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Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1.

2 October 2017

1 reference

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Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia

2 October 2017

1 reference

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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

2 October 2017

1 reference

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Combinatorial patterns of histone acetylations and methylations in the human genome

2 October 2017

1 reference

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Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation

2 October 2017

1 reference

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Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.

2 October 2017

1 reference

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Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms

2 October 2017

1 reference

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CK2 as a positive regulator of Wnt signalling and tumourigenesis

2 October 2017

1 reference

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Ikaros SUMOylation: switching out of repression

2 October 2017

1 reference

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Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition

2 October 2017

1 reference

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A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains

2 October 2017

1 reference

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Ikaros regulates neutrophil differentiation

2 October 2017

1 reference

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Unconventional potentiation of gene expression by Ikaros

2 October 2017

1 reference

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Forced expression of the Ikaros 6 isoform in human placental blood CD34(+) cells impairs their ability to differentiate toward the B-lymphoid lineage

2 October 2017

1 reference

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Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

2 October 2017

1 reference

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Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

2 October 2017

1 reference

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Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

2 October 2017

1 reference

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Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

2 October 2017

1 reference

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Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.

2 October 2017

1 reference

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The Ikaros gene is required for the development of all lymphoid lineages

2 October 2017

1 reference

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LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes

2 October 2017

1 reference

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Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment

2 October 2017

1 reference

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Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle.

2 October 2017

1 reference

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Stage-specific control of early B cell development by the transcription factor Ikaros

2 July 2018

1 reference

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Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

23 September 2018

1 reference

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Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.

23 September 2018

1 reference

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Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation

23 September 2018

1 reference

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On CK2 regulation of chronic lymphocytic leukemia cell viability.

23 September 2018

1 reference

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Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia

23 September 2018

1 reference

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Lentivirus vectors for stably introducing genes into mammary epithelial cells in vivo.

23 September 2018

1 reference

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Ikaros is critical for B cell differentiation and function.

23 September 2018

1 reference

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Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

23 September 2018

1 reference

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Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26219304

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26219304

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2015-06-651505

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26219304%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26219304%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

26219304

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26219304%20AND%20SRC:MED&resulttype=core&format=json