mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation. (Q36156993)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867072%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation (English)

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5 March 2020

1 reference

4

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5 March 2020

Jian Yu

5

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5 March 2020

author name string

K He

1

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5 March 2020

X Zheng

2

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5 March 2020

M Li

3

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5 March 2020

language of work or name

English

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publication date

13 April 2015

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5 March 2020

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5 March 2020

volume

35

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5 March 2020

issue

2

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5 March 2020

page(s)

148-157

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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

5 March 2020

cites work

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2 October 2017

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Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.

2 October 2017

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2 October 2017

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2 October 2017

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Crizotinib induces PUMA-dependent apoptosis in colon cancer cells

2 October 2017

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2 October 2017

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eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies

2 October 2017

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2 October 2017

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The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.

2 October 2017

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The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and

2 October 2017

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A unifying model for mTORC1-mediated regulation of mRNA translation.

2 October 2017

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The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction.

2 October 2017

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mTOR signaling in growth control and disease

2 October 2017

1 reference

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Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth

2 October 2017

1 reference

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mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors

2 October 2017

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2 October 2017

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mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways

2 October 2017

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2 October 2017

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Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway

2 October 2017

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PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.

2 October 2017

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The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

2 October 2017

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4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

2 October 2017

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The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation

2 October 2017

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Mitochondrial signaling in cell death via the Bcl-2 family

2 October 2017

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Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer

2 October 2017

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PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis

2 October 2017

1 reference

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2 October 2017

1 reference

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Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice

2 October 2017

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Targeting the extrinsic apoptosis pathway in cancer

2 October 2017

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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

2 October 2017

1 reference

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Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma.

2 October 2017

1 reference

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Chemosensitization of head and neck cancer cells by PUMA

2 October 2017

1 reference

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Genetic knockouts and knockins in human somatic cells

2 October 2017

1 reference

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Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

2 October 2017

1 reference

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The Bcl-2 apoptotic switch in cancer development and therapy

2 October 2017

1 reference

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PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation

2 October 2017

1 reference

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Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer

2 October 2017

1 reference

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Translational control in stress and apoptosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603992

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

2 October 2017

1 reference

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PUMA mediates the apoptotic response to p53 in colorectal cancer cells

2 October 2017

1 reference

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PUMA induces the rapid apoptosis of colorectal cancer cells

2 October 2017

1 reference

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Role of BAX in the apoptotic response to anticancer agents

2 October 2017

1 reference

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

2 October 2017

1 reference

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Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

2 October 2017

1 reference

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Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.

2 October 2017

1 reference

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2 July 2018

1 reference

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Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

23 September 2018

1 reference

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23 September 2018

Identifiers

DOI

10.1038/ONC.2015.79

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867072%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867072%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

25867072

1 reference