The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma (Q36160258)

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7 February 2020

title

The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma (English)

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7 February 2020

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4

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Evon Poon

5

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Florence Raynaud

20

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Simon P Robinson

22

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Louis Chesler

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23

Nathanael S Gray

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6

Takaomi Sanda

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7 February 2020

author name string

Teeara Berry

1

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7 February 2020

William Luther

2

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Namrata Bhatnagar

3

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Desheng Pei

7

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Bandana Sharma

8

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Winston R Vetharoy

9

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Albert Hallsworth

10

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Zai Ahmad

11

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Karen Barker

12

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Lisa Moreau

13

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Hannah Webber

14

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Wenchao Wang

15

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Antonio Perez-Atayde

17

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Scott Rodig

18

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Nai-Kong Cheung

19

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Bengt Hallberg

21

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Andrew D J Pearson

24

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Suzanne A Eccles

25

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Rani E George

27

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Qingsong Liu

16

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publication date

1 July 2012

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7 February 2020

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7 February 2020

volume

22

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7 February 2020

issue

1

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7 February 2020

page(s)

117-130

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Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

7 February 2020

cites work

1 reference

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Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417812

Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma

2 October 2017

1 reference

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Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.

2 October 2017

1 reference

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ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

2 October 2017

1 reference

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SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability

2 October 2017

1 reference

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The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers

2 October 2017

1 reference

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Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.

2 October 2017

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2 October 2017

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Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

2 October 2017

1 reference

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2 October 2017

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2 October 2017

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BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists

2 October 2017

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2 October 2017

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Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

2 October 2017

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Distinct thresholds govern Myc's biological output in vivo

2 October 2017

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Activating mutations in ALK provide a therapeutic target in neuroblastoma

2 October 2017

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Oncogenic mutations of ALK kinase in neuroblastoma

2 October 2017

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Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

2 October 2017

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Identification of ALK as a major familial neuroblastoma predisposition gene

2 October 2017

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Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance

2 October 2017

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2 October 2017

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Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

2 October 2017

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The c-myc promoter: still MysterY and challenge

2 October 2017

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Conditional transgenic models define how MYC initiates and maintains tumorigenesis

2 October 2017

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Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma.

2 October 2017

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2 October 2017

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Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Targeted expression of MYCN causes neuroblastoma in transgenic mice

2 October 2017

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2 October 2017

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2 October 2017

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Negative autoregulation of c-myc transcription

2 October 2017

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2 October 2017

The p53-Bcl-2 connection

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5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice

2 July 2018

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Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417812

Characterization of the expression of the ALK receptor tyrosine kinase in mice

23 September 2018

1 reference

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MYCN expression is not prognostic of adverse outcome in advanced-stage neuroblastoma with nonamplified MYCN

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22789543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22789543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2012.06.001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22789543%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22789543%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

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