Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. (Q36161382)

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English	Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.	scientific article

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19 December 2019

Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization (English)

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19 December 2019

phosphorylation

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19 December 2019

Christian Wolfrum

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Christian Wolfrum

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19 December 2019

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Edlira Luca

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19 December 2019

Markus Stoffel

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19 September 2003

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19 December 2019

Proceedings of the National Academy of Sciences of the United States of America

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19 December 2019

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19 December 2019

11624-11629

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19 December 2019

Extended longevity in mice lacking the insulin receptor in adipose tissue

1 reference

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2 October 2017

Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells

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2 October 2017

Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.

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2 October 2017

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

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2 October 2017

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

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2 October 2017

Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells.

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2 October 2017

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

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2 October 2017

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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2 October 2017

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

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2 October 2017

Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte

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2 October 2017

Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver- and kidney-derived cell lines

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2 October 2017

Cellular survival: a play in three Akts

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2 October 2017

Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice

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2 October 2017

Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription

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2 October 2017

Direct control of the Forkhead transcription factor AFX by protein kinase B

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2 October 2017

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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2 October 2017

Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes

1 reference

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2 October 2017

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

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Role of translocation in the activation and function of protein kinase B

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2 October 2017

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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2 October 2017

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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2 October 2017

Hepatic nuclear factor 3 and high mobility group I/Y proteins bind the insulin response element of the insulin-like growth factor-binding protein-1 promoter

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Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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2 October 2017

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

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2 October 2017

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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2 October 2017

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The winged-helix DNA-binding motif: another helix-turn-helix takeoff

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2 October 2017

A C. elegans mutant that lives twice as long as wild type

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2 October 2017

Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.

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2 October 2017

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2 October 2017

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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2 October 2017

Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes

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2 October 2017

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2 July 2018

Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.

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23 September 2018

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

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23 September 2018

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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23 September 2018

Protein kinase B beta/Akt2 plays a specific role in muscle differentiation.

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23 September 2018

Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites.

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Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate.

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Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin

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21 January 2018

Identifiers

10.1073/PNAS.1931483100

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19 December 2019

2003PNAS..10011624W

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19 December 2019

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19 December 2019

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