HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells (Q36171328)

12 August 2017

HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells (English)

1 reference

12 August 2017

V P Dave

1

1 reference

12 August 2017

D Allman

2

1 reference

12 August 2017

R Keefe

3

1 reference

12 August 2017

R R Hardy

4

1 reference

12 August 2017

D J Kappes

5

1 reference

12 August 2017

language of work or name

English

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publication date

1 July 1998

1 reference

Proceedings of the National Academy of Sciences of the United States of America

12 August 2017

1 reference

12 August 2017

95

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12 August 2017

14

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12 August 2017

8187-8192

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A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

CD8 lineage commitment in the absence of CD8.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Evidence for differential intracellular signaling via CD4 and CD8 molecules

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

T cell development in mice lacking the CD3-zeta/eta gene.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Maturational arrest from CD4+8+ to CD4+8- thymocytes in a mutant strain (LEC) of rat.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Mice lacking MHC class II molecules

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Profound block in thymocyte development in mice lacking p56lck

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Requirement for CD8 beta chain in positive selection of CD8-lineage T cells

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20951

Another view of the selective model of thymocyte selection.

2 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

Helper T-cell development in the absence of CD4-p56 Ick association

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

Inheritance of T helper immunodeficiency (thid) in LEC mutant rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.14.8187

CD4+8- and CD4-8+ mature thymocytes require different post-selection processing for final development

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9653162

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Recent thymic emigrants are distinct from most medullary thymocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9653162

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.95.14.8187

1 reference

12 August 2017

0 references

1 reference

12 August 2017

1 reference