Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML. (Q36177937)

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6 February 2020

title

Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML (English)

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6 February 2020

7

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Eun-Young Ahn

8

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Hans Beier Ommen

11

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Peter Hokland

13

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14

Cheryl L Willman

1 reference

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6 February 2020

author name string

Miao-Chia Lo

1

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6 February 2020

Luke F Peterson

2

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Ming Yan

3

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6 February 2020

Xiuli Cong

4

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Fulai Jin

5

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Wei-Jong Shia

6

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Yukiko Komeno

9

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Minh Ly

10

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I-Ming Chen

12

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Bing Ren

15

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Dong-Er Zhang

16

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6 February 2020

language of work or name

English

0 references

publication date

26 June 2012

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6 February 2020

number of pages

12

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based on heuristic

inferred from page(s)

published in

Blood

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volume

120

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6 February 2020

issue

7

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6 February 2020

page(s)

1473-1484

1 reference

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The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation

6 February 2020

cites work

1 reference

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Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes

1 October 2017

1 reference

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Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

1 October 2017

1 reference

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AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets

1 October 2017

1 reference

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RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis

1 October 2017

1 reference

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Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

1 October 2017

1 reference

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AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain

1 October 2017

1 reference

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Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.

1 October 2017

1 reference

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Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.

1 October 2017

1 reference

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Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia

1 October 2017

1 reference

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The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation

1 October 2017

1 reference

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The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423785

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

1 October 2017

1 reference

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Gene expression profiles in acute myeloid leukemia with common translocations using SAGE.

1 October 2017

1 reference

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Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt.

1 October 2017

1 reference

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Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development

1 October 2017

1 reference

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The 8;21 translocation in leukemogenesis

1 October 2017

1 reference

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Trans-activators regulating neuronal glucose transporter isoform-3 gene expression in mammalian neurons

1 October 2017

1 reference

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Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

1 October 2017

1 reference

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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

1 October 2017

1 reference

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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

1 October 2017

1 reference

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Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

1 October 2017

1 reference

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

1 October 2017

1 reference

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In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

1 October 2017

1 reference

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The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

1 October 2017

1 reference

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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

1 October 2017

1 reference

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Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

1 October 2017

1 reference

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CD45: new jobs for an old acquaintance

1 October 2017

1 reference

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CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

1 October 2017

1 reference

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AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

1 October 2017

1 reference

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Three zinc finger nuclear proteins, Sp1, Sp3, and a ZBP-89 homologue, bind to the cyclic adenosine monophosphate-responsive sequence of the bovine adrenodoxin gene and regulate transcription

1 October 2017

1 reference

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A developmentally regulated GAGA box-binding factor and Sp1 are required for transcription of the hsp70.1 gene at the onset of mouse zygotic genome activation.

1 October 2017

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

1 October 2017

1 reference

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ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423785

The AML1/ETO fusion protein activates transcription of BCL-2

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423785

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

1 October 2017

1 reference

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Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423785

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

1 October 2017

1 reference

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Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

1 October 2017

1 reference

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Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3423785

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

1 October 2017

1 reference

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CD133-enriched CD34(-) (CD33/CD38/CD71)(-) cord blood cells acquire CD34 prior to cell division and hematopoietic activity is exclusively associated with CD34 expression.

2 July 2018

1 reference

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NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

23 September 2018

1 reference

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Gene expression profiling of pediatric acute myelogenous leukemia

23 September 2018

1 reference

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Prognostically useful gene-expression profiles in acute myeloid leukemia.

23 September 2018

1 reference

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Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

23 September 2018

1 reference

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Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

23 September 2018

1 reference

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Acute myelogenous leukemia with an 8;21 translocation. A report on 148 cases from the Groupe Français de Cytogénétique Hématologique

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22740448

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2011-12-395335

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22740448%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

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6 February 2020

PubMed publication ID

22740448

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22740448%20AND%20SRC:MED&resulttype=core&format=json